Results 41 to 50 of about 160 (118)

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions

Scientific Reports
Homologous vaccination has proven to be an effective tool to control and eradicate lumpy skin disease. However, their use has been met with some trepidation for diverse reasons, in some regions, and has resulted in the use of heterologous vaccines ...
Andy Haegeman, Wannes Philips, Laurent Mostin, Ilse De Leeuw, Willem Van Campe, Claude Saegerman, Kris De Clercq, Nick De Regge   +7 more
doaj   +1 more source

Which Proteins? The Challenge of Identifying the Protective Antigens for Next-Generation Capripoxvirus Vaccines

Vaccines
Sheeppox, goatpox, and lumpy skin disease continue to negatively impact the sheep, goat, and cattle industries in countries where these diseases are present and threaten to spread into new regions. Effective vaccines are available for disease control and
Mahder Teffera, Hani Boshra, Timothy R. Bowden, Shawn Babiuk   +3 more
doaj   +1 more source

Epidemiological Study and Molecular Characterization of Lumpy Skin Disease in Cattle in Egypt

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Lumpy skin disease virus (LSDV) constitutes one of the most significant poxvirus infections impacting livestock and has a high morbidity rate and a comparatively low mortality rate. This study was designed to elucidate the epidemiology and the molecular analysis of LSDV using conventional polymerase chain reaction (PCR) to amplify the extracellular ...
Heba Hassan El-Nady, Ahmed Mansour, Mohamed Ibrahim Eissa, Naser Zeidan Abou-Zeid, Elshaima Mohamed Fawzi, Amal Mokhtar Abd El-Raof, Abdelrhman Awad Sobeih, Mohamed Mansour Bakrash, Yousry Abdelfatah El Shazly, Abdelfattah Selim   +9 more
wiley   +1 more source

Implementation of a Deep Learning System for Detection and Classification of Lumpy Skin Disease in Cattle: Enhancing Precision and Efficiency in Veterinary Diagnostics

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
GRAPHICAL ABSTRACT A deep learning system for the classification of lumpy skin disease in cattle is reported. Here, a novel ensemble model to leverage the strengths of ViT and ConvMixer models demonstrates the importance of model diversity in achieving high diagnostic performance.
Madhumita Pal, Soudamini Behera, Ranjan K. Mohapatra, Francesco Branda, Gaber A. M. Mersal, Snehasish Mishra, Salah M. El‐Bahy, Gurudutta Pattnaik, Sovan Pattanaik, Md Sajid Ali, Amiyakanta Mishra, Lawrence Sena Tuglo, Mona Youssef   +12 more
wiley   +1 more source

Establishment of a Challenge Model for Sheeppox Virus Infection

Microorganisms, 2020
Sheeppox virus (SPPV) together with goatpox virus and lumpy skin disease virus form the genus Capripoxvirus of the Poxviridae family. Due to their great economic importance and major impact on livelihood of small-scale farmers, OIE guidelines classify ...
Janika Wolff, Sahar Abd El Rahman, Jacqueline King, Mohamed El-Beskawy, Anne Pohlmann, Martin Beer, Bernd Hoffmann   +6 more
doaj   +1 more source

Characterization of a Nigerian Lumpy Skin Disease Virus Isolate after Experimental Infection of Cattle

Pathogens, 2021
Lumpy skin disease virus (LSDV), together with sheeppox virus and goatpox virus, belong to the genus Capripoxvirus within the family Poxviridae. Collectively, they are considered the most serious poxvirus diseases of agricultural livestock.
Janika Wolff, Eeva Tuppurainen, Adeyinka Adedeji, Clement Meseko, Olayinka Asala, Jolly Adole, Rebecca Atai, Banenat Dogonyaro, Anja Globig, Donata Hoffmann, Martin Beer, Bernd Hoffmann   +11 more
doaj   +1 more source

A Genome‐Wide Screening of Novel Immunogenic TrLSDV103 Protein of Lumpy Skin Disease Virus and Its Application for DIVA

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Using the VirScan platform covering 4522 LSDV protein sequences, sera from 20 LSDV‐infected and 20 GTPV‐vaccinated cattle were used to screen phage libraries. Sequencing and bioinformatics analyses revealed peptides covering the TrLSDV103 protein. The candidate antigen was subsequently expressed, confirmed for its DIVA capability, and used to develop ...
Xinwei Yuan, Junhua Dong, Zhijie Xiang, Qian Zhang, Pan Tao, Aizhen Guo   +5 more
wiley   +1 more source

The Importance of Quality Control of LSDV Live Attenuated Vaccines for Its Safe Application in the Field

Vaccines, 2021
Vaccination is an effective approach to prevent, control and eradicate diseases, including lumpy skin disease (LSD). One of the measures to address farmer hesitation to vaccinate is guaranteeing the quality of vaccine batches.
Andy Haegeman, Ilse De Leeuw, Meruyert Saduakassova, Willem Van Campe, Laetitia Aerts, Wannes Philips, Akhmetzhan Sultanov, Laurent Mostin, Kris De Clercq   +8 more
doaj   +1 more source

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, Volume 9, Issue 5, May 2025.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source