Results 81 to 90 of about 56,726 (258)

Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells.

PLoS ONE, 2012
BackgroundMammalian Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that is required for the production of intestinal mucus and Paneth and goblet cell homeostasis. However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-
Yi-Chung Chen, Yu-Fen Lu, I-Chen Li, Sheng-Ping L Hwang   +3 more
doaj   +1 more source

Age-related decline in goblet cell numbers and mucin content of the human colon: Implications for lower bowel functions in the elderly

Experimental and Molecular Pathology
Background & aims: Older people experience a greater incidence of lower bowel disorders, including constipation. Causes can include factors associated with growing older, such as use of medications or disease, but compounded by degenerative changes ...
Nicholas Baidoo, Gareth J. Sanger
doaj   +1 more source

Light microscopic study on the absorptive cells and goblet cells in the intestine of adult common carp Cyprinus carpio

The Iraqi Journal of Veterinary Medicine, 2019
The purpose of this study was to describe of some histological structures and histochemical features of the absorptive cells and goblet cells in intestine of common carp. In this study, Fifteen adult male common carp were catching alive from the AL-Forat
Khalid Hadi Kadhim
doaj   +1 more source

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, EarlyView.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

Ultrastructural and histological study of intestine of adult Nile Tilapia (Oreochromis Niloticus) [PDF]

Benha Veterinary Medical Journal
The tilapia intestine is essential for both digestion and nutrient absorption, making its structural analysis crucial for understanding its functional adaptations. This study sought to examine the histological, ultrastructural, and histochemical features
Yasmeen Ali, Aya Tantawy, Eman Khalil
doaj   +1 more source

A novel mouse model of chronic Pseudomonas aeruginosa infection inducing bronchiectasis‐like phenotype

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract highlights a bronchiectasis mouse model driven by chronic Pseudomonas aeruginosa (CPA)‐loaded agar beads plus papain, which reproduces significant airway structural damage, inflammation, mucous overproduction, and functional impairment, providing a clinically relevant platform for studying disease mechanisms and evaluating ...
Heng Yang, Yang Liu, Yuqing Wang, Yuhua Wen, Yan Chen, Rui Fan, Jiayan Xu, Shunlian Hu, Hao Qian, Rui Jiang, Weijun Cao, Jinfu Xu   +11 more
wiley   +1 more source

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

Cell Reports, 2015
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus.
Henry Danahay, Angelica D. Pessotti, Julie Coote, Brooke E. Montgomery, Donghui Xia, Aaron Wilson, Haidi Yang, Zhao Wang, Luke Bevan, Chris Thomas, Stephanie Petit, Anne London, Peter LeMotte, Arno Doelemeyer, Germán L. Vélez-Reyes, Paula Bernasconi, Christy J. Fryer, Matt Edwards, Paola Capodieci, Amy Chen, Marc Hild, Aron B. Jaffe   +21 more
doaj   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Role of epidermal growth factor receptor activation in regulating mucin synthesis

Respiratory Research, 2001
Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death.
Nadel Jay A
doaj   +1 more source

Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix

World Journal of Surgical Oncology, 2008
Background Goblet cell carcinoids appear less frequently in the appendix than do other carcinoids. In the presented work a case with a goblet cell carcinoid of the appendix is described.
Prangova Diana K, Hadjipetkov Philip, Vlaykova Tatyana, Yovchev Yovcho, Gulubova Maya V, Popharitov Angel   +5 more
doaj   +1 more source