Results 111 to 120 of about 228,960 (304)

Chemisorption vs. Physisorption in Perfluorinated Zn(II) Porphyrin–SnO₂ Hybrids for Acetone Chemoresistive Detection

Molecules
In this study, the integration of SnO2 with a perfluorinated Zn(II) porphyrin derivative, namely ZnTPPF20CN, was explored as a strategy to enhance the performance of chemoresistive sensors toward gaseous acetone detection.
Manuel Minnucci, Sara Oregioni, Eleonora Pargoletti, Gabriele Di Carlo, Francesca Tessore, Gian Luca Chiarello, Rocco Martinazzo, Mario Italo Trioni, Giuseppe Cappelletti   +8 more
doaj   +1 more source

Molecular insights into the transport lectin function of ERGIC-53 [PDF]

, 2004
Secretion of proteins is an essential function of eukaryotic cells. The secretory proteins’ journey along the organelles of the exocytic pathway is initiated by the exit from the endoplasmic reticulum (ER), which defines a major rate-limiting step for ...
Appenzeller-Herzog, Christian
core   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Frontotemporal lobar degeneration complexity: atypical presentations and heterogeneous proteinopathies in five cases

Frontiers in Neuroscience
IntroductionFrontotemporal lobar degeneration (FTLD) encompasses heterogeneous clinical syndrome within the frontotemporal spectrum, where clinicopathological associations may be misleading.
Giulia Negro, Giulia Negro, Camilla Poloni, Valentina Medici, Chiara Calatozzolo, Alessandra Canazza, Riccardo Rocco Ferrari, Chiara Cutaia, Annalisa Davin, Tino Emanuele Poloni, Tino Emanuele Poloni   +10 more
doaj   +1 more source

Center of Golgi cisternae at higher magnification [Secretory pathway; 6f]

, 2014
Presents details of the Golgi matrix and tethered transport vesicles are revealed. Clathrin coated buds are readily apparent on the trans-most cisternae and post-Golgi compartments.
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core  

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab

Biology Open, 2022
Levente Kovacs, Agnieszka Fatalska, David M. Glover   +2 more
doaj   +1 more source

Life Cycle Assessment of Swimming Goggles: Evaluating Environmental Impact and Consumer Awareness

Journal of Experimental and Theoretical Analyses
This study evaluates the environmental impact of swimming goggles through a Life Cycle Assessment (LCA), comparing virgin and recycled polycarbonate models.
Vasilissa Nikonova, Veronica Bortolotto, Costanza Bebber, Irene Presti, Gabriele Angelo Valtorta, Serena Biella, Claudia Letizia Bianchi   +6 more
doaj   +1 more source

Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p

, 2017
ADP ribosylation factor (Arf) GTPases are key regulators of membrane traffic at the Golgi complex. In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates Arf-like protein Arl1p, which was accompanied by accumulation of golgin Imh1p at ...
Hsu, Jia-Wei;Tang, Pei-Hua;Wang, I-Hao;Liu, Chia-Lun;Chen, Wen-Hui;Tsai, Pei-Chin;Chen, Kuan-Yu;Chen, Kuan-Jung;Yu, Chia-Jung;Lee, Fang-Jen S., 李芳仁   +1 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source