Results 201 to 210 of about 956,222 (367)

Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3

open access: yesThe FEBS Journal, EarlyView.
Vesicle trafficking governs the biosynthesis of heparan sulfate (HS) by controlling the positioning of HS‐modifying enzymes within Golgi compartments. The proteins Rab1A and Rab2A play dynamic, compensatory roles that affect HS levels by influencing the transport of these enzymes.
Maria C. Z. Meneghetti   +4 more
wiley   +1 more source

The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders. [PDF]

open access: yesCells, 2023
Mohan AG   +5 more
europepmc   +1 more source

Molecular Pathway of Microtubule Organization at the Golgi Apparatus.

open access: yesDevelopmental Cell, 2016
Jingchao Wu   +15 more
semanticscholar   +1 more source

Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids

open access: yesThe FEBS Journal, EarlyView.
Solid tumors have a complex extracellular matrix (ECM) that can significantly affect tumor behavior and treatment response. Understanding the role of the ECM is therefore critical for understanding tumor biology and improving therapeutic responses. In this study, we isolated primary cells from a DMBA‐induced tumor mass to generate three‐dimensional ...
Alessandra Lo Cicero   +6 more
wiley   +1 more source

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

open access: yesThe FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert   +16 more
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

open access: yesThe FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés   +19 more
wiley   +1 more source

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

open access: yesThe FEBS Journal, EarlyView.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

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