Results 71 to 80 of about 957,365 (341)
Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion
Journal of Virology, 2014 The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
A. Mousnier +7 more
semanticscholar +1 more source
Structural organization of the Golgi apparatus [PDF]
Current Opinion in Cell Biology, 2011 The Golgi apparatus is a universal feature of eukaryotes, carrying out the key functions of processing, sorting and trafficking of newly synthesized membrane and secretory proteins. The Golgi apparatus has a clearly defined structure, comprising stacks of flattened cisternal membranes that in vertebrates are connected to form a ribbon.
openaire +3 more sources
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Bio-Protocol, 2015 The plant Golgi apparatus is composed of numerous stacks of cisterna, designated as cis, medial, and trans Golgi cisternae; these stacks move within the cytoplasm along the actin cytoskeleton.
Satoshi Naramoto +2 more
doaj +1 more source
Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. [PDF]
PLoS ONE, 2012 Endothelial nitric oxide synthase (eNOS) is primarily localized on the Golgi apparatus and plasma membrane caveolae in endothelial cells. Previously, we demonstrated that protein S-nitrosylation occurs preferentially where eNOS is localized.
Panjamaporn Sangwung +5 more
doaj +1 more source
Advanced Science, EarlyView.The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu +8 more
wiley +1 more source
Stacks on tracks: the plant Golgi apparatus traffics on an actin/ER network.
The Plant Journal, 1998 We have visualized the relationship between the endoplasmic reticulum (ER) and Golgi in leaf cells of Nicotiana clevelandii by expression of two Golgi proteins fused to green fluorescent protein (GFP).
P. Boevink +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang +11 more
wiley +1 more source
The Golgin Family of Coiled-Coil Tethering Proteins
Frontiers in Cell and Developmental Biology, 2016 The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an evolutionary conserved function.
Tomasz M Witkos, Martin eLowe
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Urothelial plaque formation in post-Golgi compartments. [PDF]
PLoS ONE, 2011 Urothelial plaques are specialized membrane domains in urothelial superficial (umbrella) cells, composed of highly ordered uroplakin particles. We investigated membrane compartments involved in the formation of urothelial plaques in mouse umbrella cells.
Samo Hudoklin +4 more
doaj +1 more source