Results 91 to 100 of about 18,240,259 (142)

GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway

Frontiers in Genetics
BackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie, Shao Xie, Jiahai Ding, Zhaohao Wang, Hengliang Shi, Zheng-Quan Yu   +5 more
doaj   +1 more source

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
core   +1 more source

Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

The Journal of Clinical Investigation
Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer.
Xiaochao Tan, Shike Wang, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Yu Jiang, Dzifa Y. Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A. Roth, Michael P. Kim, Fengju Chen, Chad J. Creighton, William K. Russell, Jonathan M. Kurie   +17 more
doaj   +1 more source

FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer

Frontiers in Oncology, 2019
Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS.
Li-Na Yu, Li-Na Yu, Li-Na Yu, Zhen Liu, Yan Tian, Yan Tian, Yan Tian, Pei-Pei Zhao, Pei-Pei Zhao, Pei-Pei Zhao, Xing Hua   +10 more
doaj   +1 more source

Correction: Ruggiero et al. Golgi Phosphoprotein 3 Regulates the Physical Association of Glycolipid Glycosyltransferases. Int. J. Mol. Sci. 2022, 23, 10354. [PDF]

Int J Mol Sci, 2023
Ruggiero FM, Martínez-Koteski N, Cavieres VA, Mardones GA, Fidelio GD, Vilcaes AA, Daniotti JL.   +6 more
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Supplementary Material for: Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

, 2018
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Zhang H. (2945919), Lu D. (5496260), Zhou X. (3627416), Fu J. (5496266), Wu S. (3601439), Wang X. (2828795), Yu R. (3722539), Qi Y. (5496263)   +7 more
core   +1 more source

The role of GRASP65 and GRASP55 in C-terminal valine-dependent transport to the cell surface of transmembrane proteins [PDF]

, 2008
The Golgi-matrix proteins GRASP65 and GRASP55 have recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion while, surprisingly, they have been shown to be dispensable for the ...
Prencipe, Libera
core   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2010
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Sue E Crawford, Mary K Estes, Mary K. Estes, Susana Guix, Kazuhiko Katayama, Sue E. Crawford, Tyler M Sharp, Tyler M. Sharp, Guix Arnau, Susana, Katayama, K., Guix Susana, Crawford, Sue E., Estes, M. K., Katayama Kazuhiko, Estes Mary K., Sharp, T. M., Sharp Tyler M., Crawford Sue E.   +17 more
core   +2 more sources

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]

, 2013
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang, Ackema, K. B., Jachen A Solinger, Karin B Ackema, Ursula Sauder, Solinger, J. A., Karin B. Ackema, Jachen A. Solinger (254344), Jachen A. Solinger, Karin B. Ackema (423507), Ursula Sauder (250540), Spang, A., Anne Spang (205738), Sauder, U.   +13 more
core   +2 more sources