Results 31 to 40 of about 18,240,259 (142)

The diagnostic/prognostic significance of serum Golgi phosphoprotein 3 in ovarian cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Ovarian cancer (OC) is a serious healthcare problem and early detection is a fundamental stone in improving patient survival. Golgi phosphoprotein 3 (GOLPH3) is found to be increased in various cancers including OC. This study aimed to investigate GOLPH3
Elshamly, Eman M., Sanad, Eman F., Gad, Haitham F., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

"In vitro" reconstitution of "trans"-Golgi exit and the effect of GAG attachment on protein sorting [PDF]

, 2007
The trans-Golgi network is one of the main sorting stations for proteins and lipids in the eukaryotic endomembrane system. Yet, the mechanisms for sorting and transport out of the trans-Golgi network remain poorly understood.
Kobialka, Szymon
core   +1 more source

GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response

Cell Death and Disease, 2023
Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is associated with a high morbidity and mortality. Understanding the molecular mechanisms underlying the acute
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park   +5 more
doaj   +1 more source

Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth

Cells, 2023
The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional status and growth factors.
Anna Frappaolo, Maria Grazia Giansanti
doaj   +1 more source

The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi [PDF]

, 1991
A procedure has been established in Vero cells for the isolation of an intermediate compartment involved in protein transport from the ER to the Golgi apparatus. The two-step subcellular fractionation procedure consists of Percoll followed by Metrizamide
K Matter, Ketcham, C. M., Schweizer, A., A Schweizer, C M Ketcham, Matter, K., Hauri, H. P., H P Hauri   +7 more
core   +1 more source

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network [PDF]

, 2008
The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion ...
Amessou, M, Boal, Frédéric, Mohammed, Ludger, Roberts, LM, Stephens, David J, Smith, Daniel C., Clarkson, GJ, Stephens, D. J., Lord, JM, Clarkson, Guy J., Clarkson, Guy J, Roberts, Lynne M, Amessou, M., Watson, Peter D, Lord, J. M., Watson, Peter, Roberts, L. M. (Lynne M.), Amessou, Mohammed, Spooner, Robert A, Boal, F., Johannes, L., Smith, D. C., Smith, Daniel C, Clarkson, G. J., Spooner, Robert A., Stephens, David J., Watson, P, Smith, DC, Lord, J. Michael, Johannes, Ludger, Lord, Mike, Johannes, L, Spooner, RA, Boal, F, Stephens, DJ, Spooner, R. A., Watson, Peter Duncan, Roberts, L. M.   +37 more
core   +1 more source

Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway

BMC Pulmonary Medicine, 2023
Purpose Endotoxin-induced acute lung injury (ALI) is a severe disease caused by an imbalanced host response to infection. It is necessary to explore novel mechanisms for the treatment of endotoxin-induced ALI.
Shaona Li, Yexiang Xu, Simeng He, Xiangyun Li, Jia Shi, Bing Zhang, Youzhuang Zhu, Xiangkun Li, Yanting Wang, Cuicui Liu, Yang Ma, Shuan Dong, Jianbo Yu   +12 more
doaj   +1 more source

GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila

Cell Death and Disease, 2022
The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human
Anna Frappaolo, Angela Karimpour-Ghahnavieh, Giuliana Cesare, Stefano Sechi, Roberta Fraschini, Thomas Vaccari, Maria Grazia Giansanti   +6 more
doaj   +1 more source

Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway [PDF]

, 1995
ERGIC-53 is a lectin-type membrane protein that continuously recycles between the ER, ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi. To identify the targeting signals that mediate this recycling, N-glycosylated and myc-tagged variants of ...
R Schindler, Itin, C., C Itin, Schindler, R., Hauri, H. P., H P Hauri   +5 more
core   +1 more source

Linking GOLPH3 and Extracellular Vesicles Content—a Potential New Route in Cancer Physiopathology and a Promising Therapeutic Target is in Sight?

Technology in Cancer Research & Treatment, 2022
Golgi phosphoprotein 3 (GOLPH3), a highly conserved phosphatidylinositol 4-phosphate effector, is required for maintenance of Golgi architecture, vesicle trafficking, and Golgi glycosylation. GOLPH3 overexpression has been reported in several human solid
Maria Grazia Giansanti PhD, Roberto Piergentili PhD   +1 more
doaj   +1 more source