Results 151 to 160 of about 1,450 (167)

GOLPH3 promotes tumor malignancy via inhibition of ferroptosis by upregulating SLC7A11 in cholangiocarcinoma

Molecular Carcinogenesis
Golgi phosphoprotein 3 (GOLPH3) has been reported as an oncogene in various tumors; however, the role and function of GOLPH3 and its relevant molecular mechanism in cholangiocarcinoma (CCA) are unclear.
Zheng-Wei Yin, Qi Liu, Ying Gao, Ruizhi Wang, Yunling Qi, Dong Wang, Lianzhou Chen, Xiaoyu Yin, Meifang He, Wen Li   +9 more
semanticscholar   +1 more source

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Molecular Neurobiology, 2014
Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes.
Ting, Li, Hong, You, Jie, Zhang, Xiaoye, Mo, Wenfang, He, Yang, Chen, Xiangqi, Tang, Zheng, Jiang, Ranran, Tu, Liuwang, Zeng, Wei, Lu, Zhiping, Hu   +11 more
openaire   +2 more sources

USP6 and circCYFIP2 target oncoprotein GOLPH3 for deubiquitination and induce platinum resistance in colon cancer.

Biochemical Pharmacology
GOLPH3 has been identified as an oncoprotein, playing a crucial role on progression and chemoresistancein of colon adenocarcinoma (COAD). However, it is still unclear the regulation of GOLPH3 expression at protein level.
Shaojian Chen, Hai-Bin Zhuang, Xian Deng, Yuze Wu, Ming-liang Chen, Chunxiao Wang, Xiaojing Chen, Zhongshi Hong, Chengzhi Qiu   +8 more
semanticscholar   +1 more source

The relationship of tumor budding with GOLPH3 expression and histopathological prognostic parameters in colorectal adenocarcinoma.

Annals of Diagnostic Pathology, 2022
OBJECTIVE Tumor budding is an independent poor prognostic parameter in colorectal carcinoma (CRC). Golgi phosphoprotein 3 (GOLPH3) has been investigated in many solid organ tumors and has been associated with poor prognosis.
Neslihan Komut, S. Bektaş, Emine Yıldırım   +2 more
semanticscholar   +1 more source

GOLPH3 knockdown alleviates the inflammation and apoptosis in lipopolysaccharide-induced acute lung injury by inhibiting Golgi stress mediated autophagy.

Prostaglandins & other lipid mediators
Pneumonia, an acute inflammatory lesion of the lung, is the leading cause of death in children aged 
Yanru Wang, Xiaoxia Li, Qin Zhou, Su Zhang   +3 more
semanticscholar   +1 more source

GOLPH3 inhibition reverses oxaliplatin resistance of colon cancer cells via suppression of PI3K/AKT/mTOR pathway.

Life Science, 2020
OBJECTIVE To explore whether GOLPH3 regulated oxaliplatin (L-OHP) resistance of colon cancer cells via PI3K/AKT/mTOR pathway. METHODS HCT116/L-OHP cells were divided into Blank, Control/GOLPH3 shRNA, BEZ235 (a PI3K/AKT/mTOR inhibitor), and GOLPH3 ...
T. Yu, Q. An, Xiang-long Cao, Hua Yang, J. Cui, Zijian Li, G. Xiao   +6 more
semanticscholar   +1 more source

Environmental glyphosate exposure compromises sperm quality in mice by impairing acrosome biogenesis via GOLPH3-mediated golgiphagy.

Journal of Hazardous Materials
The escalating global incidence of male infertility is closely linked to environmental endocrine disruptors, particularly pesticides. Glyphosate (GLY) is a widely used pesticide with endocrine-disrupting activity and has been recognized to pose ...
Yu-Long Ren, Kaili Chen, Yue Li, Yan-Zhan Jia, Hao Wang, Lin Wang   +5 more
semanticscholar   +1 more source

Long noncoding RNA HOTAIR promotes breast cancer development through the lncRNA HOTAIR/miR-1/GOLPH3 axis

Clinical and Translational Oncology, 2023
Jiawen Zhao, Lei Zhang, Y. Zhao, Nan Wu, Xi Zhang, Rong Guo, Huimeng Li, Chunxiang Li, K. Zheng, Dequan Liu, Shicong Tang   +10 more
semanticscholar   +1 more source

Circ_101692 promotes the proliferation, invasion and glycolysis of colorectal cancer through the regulation of miR-449b-5p/GOLPH3 axis

Molecular & Cellular Toxicology, 2023
Xiang Feng, Qian Zhang
semanticscholar   +1 more source

GOLPH3 wt Allele

2020
openaire   +1 more source