Results 161 to 170 of about 2,164 (194)

PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in <i>Drosophila melanogaster</i>. [PDF]

Open Biol
Frappaolo A, Zaccagnini G, Riparbelli MG, Colotti G, Callaini G, Giansanti MG.   +5 more
europepmc   +1 more source

Golgi dispersal in cancer stem cells promotes chemoresistance of colorectal cancer via the Golgi stress response. [PDF]

Cell Death Dis
Li Y, Mu L, Li Y, Mi Y, Hu Y, Li X, Tao D, Qin J.   +7 more
europepmc   +1 more source

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research. [PDF]

Cell Mol Biol Lett
Szymczak-Kulus K, Czerwinski M, Kaczmarek R.   +2 more
europepmc   +1 more source

<i>Drosophila melanogaster</i>: How and Why It Became a Model Organism. [PDF]

Int J Mol Sci
Giansanti MG, Frappaolo A, Piergentili R.   +2 more
europepmc   +1 more source

Weighted Gene Networks Derived from Multi-Omics Reveal Core Cancer Genes in Lung Cancer. [PDF]

Biology (Basel)
He Q, Mi Z, Yin Z, Zheng Z, Guo B.
europepmc   +1 more source

Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer [PDF]

International Journal of Molecular Sciences, 2020
Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified
Stefano Sechi, Anna Frappaolo, Roberto Piergentili   +2 more
exaly   +5 more sources

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GOLPH3 and oncogenesis: What is the molecular link?

Tissue and Cell, 2017
The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN).
Riccardo Rizzo, Seetharaman Parashuraman, Giovanni D´Angelo   +2 more
exaly   +3 more sources

GOLPH3 regulates the migration and invasion of glioma cells though RhoA

Biochemical and Biophysical Research Communications, 2013
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition,
Xiuping Zhou, Wenjian Zhan, Shao Xie
exaly   +3 more sources

GOLPH3 Regulates Exosome miRNA Secretion in Glioma Cells

Journal of Molecular Neuroscience, 2020
We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by ultra-centrifugation from the supernatant of U251 and U87 cell cultures and identified by transmission electron microscopy (TEM), Malvern analyzer, and western blot.
Pengfei Hu, Kai Wang, Ding Zhou, Liang Wang, Min Zhao, Weibing Wang, Yu Zhang, Yushuai Liu, Rutong Yu, Xiuping Zhou   +9 more
openaire   +4 more sources

Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes

Journal of Neuro-Oncology, 2018
GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.At the cellular level, the A2-CL/siGOLPH3 ...
Shun Li, Jun Lu, Rutong Yu
exaly   +3 more sources