Results 161 to 170 of about 1,491 (187)

GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation [PDF]

International Journal of Molecular Sciences, 2020
Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLPH3),
Gonzalo A Mardones, Cecilia Arriagada, Patricia V. Burgos Hitschfeld   +2 more
exaly   +5 more sources

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GOLPH3 regulates the migration and invasion of glioma cells though RhoA

Biochemical and Biophysical Research Communications, 2013
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition,
Xiuping Zhou, Wenjian Zhan, Guanzheng Liu   +2 more
exaly   +3 more sources

Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer

Tumor Biology, 2012
This study aims to investigate the expression and significance of GOLPH3 in human gastric cancer progression and prognosis. Using immunohistochemistry (IHC) and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of GOLPH3 in gastric cancer tissues compared to paired normal stomach mucosa ...
Jian-Ping Li
exaly   +3 more sources

GOLPH3 Regulates Exosome miRNA Secretion in Glioma Cells

Journal of Molecular Neuroscience, 2020
We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by ultra-centrifugation from the supernatant of U251 and U87 cell cultures and identified by transmission electron microscopy (TEM), Malvern analyzer, and western blot.
Pengfei Hu, Kai Wang, Ding Zhou, Liang Wang, Min Zhao, Weibing Wang, Yu Zhang, Yushuai Liu, Rutong Yu, Xiuping Zhou   +9 more
openaire   +4 more sources

Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes

Journal of Neuro-Oncology, 2018
GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.At the cellular level, the A2-CL/siGOLPH3 ...
Jun Lu, Rutong Yu, Shun Li
exaly   +3 more sources

Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

Life Sciences, 2020
Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not.In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells
Li-Qun, Lu, Ming-Zhu, Tang, Zhi-Hao, Qi, Shi-Fang, Huang, Yong-Qi, He, Dian-Ke, Li, Lan-Fang, Li, Lin-Xi, Chen   +7 more
openaire   +2 more sources

GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells

Cell Biology International
AbstractFerroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not fully understood. In the present study we found that a protein enriched in the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3), was ...
Lihua Chen, Chunxiao Wang, Xiaojing Chen, Yuze Wu, Mingliang Chen, Xian Deng, Chengzhi Qiu   +6 more
openaire   +2 more sources

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Molecular Neurobiology, 2014
Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes.
Ting, Li, Hong, You, Jie, Zhang, Xiaoye, Mo, Wenfang, He, Yang, Chen, Xiangqi, Tang, Zheng, Jiang, Ranran, Tu, Liuwang, Zeng, Wei, Lu, Zhiping, Hu   +11 more
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GOLPH3 promotes tumor malignancy via inhibition of ferroptosis by upregulating SLC7A11 in cholangiocarcinoma

Molecular Carcinogenesis
AbstractGolgi phosphoprotein 3 (GOLPH3) has been reported as an oncogene in various tumors; however, the role and function of GOLPH3 and its relevant molecular mechanism in cholangiocarcinoma (CCA) are unclear. Herein, GOLPH3 expression in CCA tissues was observed to be significantly higher than that in paired adjacent noncancerous tissues ...
Wen Li, Meifang He, Xiao-Yu Yin
exaly   +3 more sources

Glycosyltransferases regulate the expression of Golgi phosphoprotein 3 (GOLPH3)

Abstract Glycosphingolipid glycosyltransferases (GGTs) can organize as multienzyme complexes localized along the Golgi complex. However, the influence of the relative presence of GGTs on the localization of their clients is unclear.
Natalia Martínez-Koteski, Fernando M. Ruggiero, Sofia Rasino, Pablo H. H. Lopez, Gerardo D. Fidelio, A. Alejandro Vilcaes, Natali L. Chanaday   +6 more
openaire   +1 more source