Results 161 to 170 of about 2,136 (186)
DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3 [PDF]
Cell, 2014 The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly. However, the cytoplasmic response to DNA damage is poorly understood. Here, we demonstrate that DNA damage triggers dramatic reorganization of the Golgi, resulting in its dispersal throughout the cytoplasm.
Marshall C Peterman, Huilin Zhou
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EMBO Journal, 2021 Glycosphingolipids are important components of the plasma membrane where they modulate the activities of membrane proteins including signalling receptors. Glycosphingolipid synthesis relies on competing reactions catalysed by Golgi-resident enzymes during the passage of substrates through the Golgi cisternae.
Riccardo Rizzo +2 more
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Efficient Golgi Forward Trafficking Requires GOLPH3-Driven, PI4P-Dependent Membrane Curvature [PDF]
Developmental Cell, 2019 Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins that induce curvature of the Golgi membrane are predicted to be required, by analogy to vesicle budding from other membranes. Here, we demonstrate that GOLPH3, upon binding to the phosphoinositide PI4P, induces curvature of synthetic membranes in vitro and the
Ramya S Kuna, Sheng Li, Norton Cheng
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GOLPH3 and oncogenesis: What is the molecular link?
Tissue and Cell, 2017The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN).
Riccardo Rizzo +2 more
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GOLPH3 Regulates Exosome miRNA Secretion in Glioma Cells
Journal of Molecular Neuroscience, 2020We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by ultra-centrifugation from the supernatant of U251 and U87 cell cultures and identified by transmission electron microscopy (TEM), Malvern analyzer, and western blot.
Pengfei Hu +9 more
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GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation
Journal of Neuro-Oncology, 2018Our recent work reported that GOLPH3 promotes glioma progression via inhibiting endocytosis and degradation of EGFR. The current study aimed to explore the potential regulating mechanism of GOLPH3 on JAK2-STAT3 signaling, a downstream effector of EGFR, in glioma progression.The expression of JAK2, STAT3 and GOLPH3 in glioma tissues was detected by ...
Rutong Yu, Xiuping Zhou
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Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy
Life Sciences, 2020Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not.In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells
Li-Qun, Lu +7 more
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GOLPH3 regulates the migration and invasion of glioma cells though RhoA
Biochemical and Biophysical Research Communications, 2013Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition,
Xiuping Zhou, Wenjian Zhan, Rutong Yu
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Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes
Journal of Neuro-Oncology, 2018GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.At the cellular level, the A2-CL/siGOLPH3 ...
Liang Zhao, Shun Li, Jun Lu
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Golph3 promotes vascular mimicry via the epithelial mesenchymal transition in glioblastoma cells
Turkish Neurosurgery, 2021To evaluate the relationship between Golgi phosphoprotein 3 (GOLPH3) and vasculogenic mimicry (VM) in glioblastoma cells.Glioma tissues from 40 glioma patients with different pathological grades were collected. GOLPH3 and VM were evaluated by immunostaining in glioma tissues.
Jun, Jia +7 more
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