Results 151 to 160 of about 2,136 (186)

Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer [PDF]

open access: yesInternational Journal of Molecular Sciences, 2020
Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified
Stefano Sechi   +2 more
exaly   +5 more sources

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer [PDF]

open access: yesNature, 2009
Genome-wide copy number analyses of human cancers identified a frequent 5p13 amplification in several solid tumour types, including lung (56%), ovarian (38%), breast (32%), prostate (37%) and melanoma (32%). Here, using integrative analysis of a genomic profile of the region, we identify a Golgi protein, GOLPH3, as a candidate targeted for ...
Mei-Chih Liang   +2 more
exaly   +3 more sources

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