Results 171 to 180 of about 2,136 (186)
GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation [PDF]
International Journal of Molecular Sciences, 2020 Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLPH3), a peripheral membrane protein mostly localized at the trans-Golgi network, is overexpressed in ...
Cecilia Arriagada +2 more
exaly +4 more sources
Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer
Tumor Biology, 2012 This study aims to investigate the expression and significance of GOLPH3 in human gastric cancer progression and prognosis. Using immunohistochemistry (IHC) and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of GOLPH3 in gastric cancer tissues compared to paired normal stomach mucosa ...
Ben-Shun, Hu +4 more
exaly +3 more sources
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GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells
Cell Biology InternationalAbstractFerroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not fully understood. In the present study we found that a protein enriched in the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3), was ...
Lihua Chen +6 more
openaire +2 more sources
Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus
Molecular Neurobiology, 2014Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes.
Ting, Li +11 more
openaire +2 more sources
CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling
Molecular and Cellular EndocrinologyOvarian cancer stands as a formidable clinical challenge, with limited therapeutic options. This investigation delves into the intricate molecular mechanisms governing ovarian cancer progression and uncovers Centromere Protein K (CENPK) as a central figure in disease pathogenesis.
Gaolian Li +14 more
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GOLPH3‐STIP1 Complex Activates STAT3 Through Exosome Secretion to Induce Colon Cancer Metastasis
Biotechnology JournalABSTRACTWith a high mortality rate, colon cancer (CC) is the third most common malignant tumor worldwide. The primary causes are thought to be the high invasiveness and migration of CC cells. The functions of Golgi phosphoprotein 3 (GOLPH3), stress‐induced phosphoprotein 1 (STIP1), and the signal transducer and activator of transcription 3 (STAT3 ...
Yanta Guo +5 more
openaire +2 more sources
GOLPH3 links the Golgi network to mTOR signaling and human cancer
Pigment Cell & Melanoma Research, 2009openaire +2 more sources