Results 171 to 180 of about 2,164 (194)

Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer

Tumor Biology, 2012
This study aims to investigate the expression and significance of GOLPH3 in human gastric cancer progression and prognosis. Using immunohistochemistry (IHC) and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of GOLPH3 in gastric cancer tissues compared to paired normal stomach mucosa ...
Ben-Shun, Hu, Hao, Hu, Cong-Yuan, Zhu, Yuan-Long, Gu, Jian-Ping, Li   +4 more
exaly   +3 more sources

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Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

Life Sciences, 2020
Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not.In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells
Li-Qun, Lu, Ming-Zhu, Tang, Zhi-Hao, Qi, Shi-Fang, Huang, Yong-Qi, He, Dian-Ke, Li, Lan-Fang, Li, Lin-Xi, Chen   +7 more
openaire   +2 more sources

The relationship of tumor budding with GOLPH3 expression and histopathological prognostic parameters in colorectal adenocarcinoma

Annals of Diagnostic Pathology, 2022
Tumor budding is an independent poor prognostic parameter in colorectal carcinoma (CRC). Golgi phosphoprotein 3 (GOLPH3) has been investigated in many solid organ tumors and has been associated with poor prognosis. In this study, the relationship of tumor budding and GOLPH3 and histopathological prognostic markers was investigated.140 colon resection ...
Neslihan, Komut, Sibel, Bektas, Emine, Yildirim   +2 more
openaire   +2 more sources

GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation

Journal of Neuro-Oncology, 2018
Our recent work reported that GOLPH3 promotes glioma progression via inhibiting endocytosis and degradation of EGFR. The current study aimed to explore the potential regulating mechanism of GOLPH3 on JAK2-STAT3 signaling, a downstream effector of EGFR, in glioma progression.The expression of JAK2, STAT3 and GOLPH3 in glioma tissues was detected by ...
Rutong Yu, Xiuping Zhou
exaly   +3 more sources

GOLPH3, a Good Prognostic Indicator in Early-stage NSCLC Related to Tumor Angiogenesis

Asian Pacific Journal of Cancer Prevention, 2014
Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC.Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of ...
Ming Lu, Shu-Hai Li, Cun Gao
exaly   +4 more sources

Golph3 promotes vascular mimicry via the epithelial mesenchymal transition in glioblastoma cells

Turkish Neurosurgery, 2021
To evaluate the relationship between Golgi phosphoprotein 3 (GOLPH3) and vasculogenic mimicry (VM) in glioblastoma cells.Glioma tissues from 40 glioma patients with different pathological grades were collected. GOLPH3 and VM were evaluated by immunostaining in glioma tissues.
Jun, Jia, Liangzhao, Chu, Xi, Zeng, Niya, Long, Minghao, Dong, Yushi, Yang, Yaxin, Hu, Jian, Liu   +7 more
openaire   +2 more sources

GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells

Cell Biology International
AbstractFerroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not fully understood. In the present study we found that a protein enriched in the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3), was ...
Lihua Chen, Chunxiao Wang, Xiaojing Chen, Yuze Wu, Mingliang Chen, Xian Deng, Chengzhi Qiu   +6 more
openaire   +2 more sources

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Molecular Neurobiology, 2014
Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes.
Ting, Li, Hong, You, Jie, Zhang, Xiaoye, Mo, Wenfang, He, Yang, Chen, Xiangqi, Tang, Zheng, Jiang, Ranran, Tu, Liuwang, Zeng, Wei, Lu, Zhiping, Hu   +11 more
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The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis

Biochemical Society Transactions, 2015
Cytokinesis is an intricate process that requires an intimate interplay between actomyosin ring constriction and plasma membrane remodelling at the cleavage furrow. However, the molecular mechanisms involved in coupling the cytoskeleton dynamics with vesicle trafficking during cytokinesis are poorly understood. The highly conserved Golgi phosphoprotein
Sechi Stefano, Frappaolo Anna, Belloni Giorgio, Giansanti Maria Grazia   +3 more
openaire   +3 more sources

Glycosyltransferases regulate the expression of Golgi phosphoprotein 3 (GOLPH3)

Abstract Glycosphingolipid glycosyltransferases (GGTs) can organize as multienzyme complexes localized along the Golgi complex. However, the influence of the relative presence of GGTs on the localization of their clients is unclear.
Natalia Martínez-Koteski, Fernando M. Ruggiero, Sofia Rasino, Pablo H. H. Lopez, Gerardo D. Fidelio, A. Alejandro Vilcaes, Natali L. Chanaday   +6 more
openaire   +1 more source