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Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis. [PDF]
Front ImmunolLuo Y +5 more
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Reproduction under Siege: How Chronic Stress Hijacks the HPG Axis?
NeuroendocrinologyXu D, Zhao X, Chen W, Liu Y, Wang C.
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Neuroscience Letters, 2003
Consistent with its neuroendocrine role, gonadotropin-releasing hormone (GnRH) is located principally within the hypothalamus, although extra-hypothalamic expression has been reported. The present study characterized the expression of GnRH and GnRH receptor (GnRH-R) in sheep spinal cord using real-time PCR and immunocytochemistry.
Neil Evans, Andrea M Nolan
exaly +3 more sources
Consistent with its neuroendocrine role, gonadotropin-releasing hormone (GnRH) is located principally within the hypothalamus, although extra-hypothalamic expression has been reported. The present study characterized the expression of GnRH and GnRH receptor (GnRH-R) in sheep spinal cord using real-time PCR and immunocytochemistry.
Neil Evans, Andrea M Nolan
exaly +3 more sources
Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta
Current Opinion in Endocrinology, Diabetes & Obesity, 2011This review summarizes our current understanding of the role of gonadotropin-releasing hormone (GnRH)/GnRH receptor (GnRHR) signaling at the maternal-fetal interface.Several isoforms of GnRH and GnRHR are described. The hypothalamic decapeptide, GnRH-I, binds to the anterior pituitary and induces the synthesis and secretion of luteinizing hormone and ...
Kirsten, Sasaki, Errol R, Norwitz
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Gonadotropin-releasing-hormone-receptor antagonists
The Lancet, 2001Pulsatile gonadotropin-releasing hormone (GnRH) stimulates the pituitary secretion of both luteinising hormone (LH) and follicle-stimulating hormone (FSH) and thus controls the hormonal and reproductive function of the gonads. Blockade of GnRH effects may be wanted for a variety of reasons-eg, to prevent untimely luteinisation during assisted ...
J A, Huirne, C B, Lambalk
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Functional domains of the gonadotropin-releasing hormone receptor
Cellular and Molecular Neurobiology, 19951. The cloning of the mammalian gonadotropin-releasing hormone receptor sets the stage for rapid progress in understanding the structure of the receptor, its interaction with ligand, and its mechanisms of activation. 2. The receptor is a 327 to 328-amino acid seven-transmembrane domain G protein-coupled receptor. 3.
S C, Sealfon, R P, Millar
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Endocrinology, 1985
Gonadotropin-releasing hormone (GnRH) induces both synthesis and release of pituitary gonadotropins, but rapid or slow frequencies of stimulation result in reduced LH and FSH secretion. We determined the effects of frequency of GnRH stimulation on pituitary GnRH receptors (GnRH-R). Castrate male rats received testosterone implants (cast + T) to inhibit
J A, Katt +4 more
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Gonadotropin-releasing hormone (GnRH) induces both synthesis and release of pituitary gonadotropins, but rapid or slow frequencies of stimulation result in reduced LH and FSH secretion. We determined the effects of frequency of GnRH stimulation on pituitary GnRH receptors (GnRH-R). Castrate male rats received testosterone implants (cast + T) to inhibit
J A, Katt +4 more
openaire +2 more sources
Endocrinology, 1982
To further evaluate the role of GnRH in the regulation of pituitary gonadotropin-releasing hormone receptors (GnRH-R) in male rats in vivo, endogenous GnRH was neutralized with a high-titer GnRH antiserum (GnRH-AS). When administered daily from the time of orchidectomy, GnRHAS prevented the 70–100% increase in GnRH-R and the 10-fold rise in serum LH ...
R N, Clayton, R M, Popkin, H M, Fraser
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To further evaluate the role of GnRH in the regulation of pituitary gonadotropin-releasing hormone receptors (GnRH-R) in male rats in vivo, endogenous GnRH was neutralized with a high-titer GnRH antiserum (GnRH-AS). When administered daily from the time of orchidectomy, GnRHAS prevented the 70–100% increase in GnRH-R and the 10-fold rise in serum LH ...
R N, Clayton, R M, Popkin, H M, Fraser
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Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor
1999Gonadotropin-releasing hormone (GnRH) is a hypothalamic decapeptide that plays a fundamental role in the reproductive events of all mammalian species. GnRH was first isolated in the early 1970s by Schally (1) and Guillemin (2). Since that time there has been an explosion of knowledge regarding the physiology and genetic structure of GnRH and its ...
Dorothy I. Shulman, Barry B. Bercu
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