Results 131 to 140 of about 17,116,045 (316)
Good Person, Good Prosecutor in 2018 [PDF]
, 2018 Nearly twenty years ago, I wrote an essay on the ethics of prosecution in a time of mass incarceration called “Can You Be a Good Person and a Good Prosecutor?” I am both pleased and perplexed that the essay, which caused some controversy at the time ...
Smith, Abbe
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Lamb Production:grazing management, breeding policy and parasite control [PDF]
, 2008 Internal parasitic infection can pose major health problems in young livestock and this is particularly so in the context of lambs in organic production systems.
Good, Barbara, Hanrahan, J.P.
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Child support enforcement for teenage fathers: Problems and prospects [PDF]
The NLSY data indicate that about 7.3 percent of teenage males become fathers and that very few of these fathers live with their children. Father absence and the concurrent increase in female-headed households are closely associated with the ...
D. H. Good, M. A. Pirog-Good
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Научный вестник МГТУ ГА, 2016 In this article, the authors considered the religious - philosophical component of Russian cosmism, its moral Foundation. A brief philosophical analysis of the problem of good and evil in the teaching of one of the representatives of religious branches ...
N. A. Nekrasova, A. G. Soshnina
doaj
The Fear of Litigation Study: The Impact of Medicine [PDF]
See related event, "Beyond the Patients' Bill of Rights: Does America Need a New System of Medical Justice Medicine is clearly a highly dynamic and ever-changing field.
Good, Common
core +1 more source