Results 171 to 180 of about 2,350,416 (333)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Evidence-Based Medicine and Good Clinical Practice in Research in Pediatric and Adolescent Medicine. [PDF]

Children (Basel)
Karatza AA, Tsintoni A, Kapnisis D, Gkentzi D, Fouzas S, Kostopoulou E, Sinopidis X, Antonakopoulos N.   +7 more
europepmc   +1 more source

"How do I keep this live in my mind?" Allied Health Professionals' perspectives of barriers and enablers to implementing good clinical practice principles in research: a qualitative exploration. [PDF]

BMC Health Serv Res, 2023
Wenke R, Roberts S, Angus R, Owusu MA, Weir K.   +4 more
europepmc   +1 more source

Inside general practice ethics: guidelines ‘and’ ‘of’ or ‘for’ good clinical practice [PDF]

, 2018
Andrew Papanikitas, Carey Lunan
openalex   +1 more source

NHMRC draft information paper: evidence on the effectiveness of homeopathy for treating health conditions [PDF]

This report summarises an assessment of homeopathy undertaken by the National Health and Medical Research Council, including an overview of published systematic reviews, evaluation of information provided by interest groups and the public, and ...

core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Quality requirements in clinical studies: a necessary burden?

Swiss Medical Weekly, 2003
M Salzberg
doaj   +1 more source

Bridging the gap in clinical research training: a qualitative study of postgraduate medical students' perceptions of good clinical practice education. [PDF]

Med Educ Online
Xiaoyun W, Zhao Y, Zeyun L, Chen X, Xuedong J, Yaowen L, Jie W, Xin T.   +7 more
europepmc   +1 more source

Survey Results and Recommendations from Japanese Stakeholders for Good Clinical Practice Renovation. [PDF]

Ther Innov Regul Sci, 2022
Nakamura K, Ozawa H, Shibata T, Ushirozawa N, Hata T, Okita N, Fuse N, Sato N, Ikeda K, Hanaoka H, Maruyama T, Wada M, Shimizu S, Kasai H, Yamamoto Y, Sakurai J, Todaka K, Tashiro S, Yamamoto H.   +18 more
europepmc   +1 more source