Results 191 to 200 of about 2,350,416 (333)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Good Clinical Practice of the Italian Society of Thalassemia and Haemoglobinopathies (SITE) for the Management of Endocrine Complications in Patients with Haemoglobinopathies. [PDF]

J Clin Med, 2022
Casale M, Baldini MI, Del Monte P, Gigante A, Grandone A, Origa R, Poggi M, Gadda F, Lai R, Marchetti M, Forni GL.   +10 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Implementation of good clinical practice in clinical research in the context of limited resources settings: Lessons learnt from the freeBILy trial using an embedded mixed methods approach. [PDF]

PLoS Negl Trop Dis
Gunga L, Rausche P, Rakotoarivelo RA, Rasamoelina M, Solonirina J, Fesia E, Razafindrakoto R, Rakotozandrindrainy N, Radomanana M, Marchese V, Issa N, Kutz JM, Remkes A, Jager A, Puraduredja DI, van Dam G, Schwarz N, May J, Rakotozandrindrainy R, Fischer N, Fusco D, freeBILy consortium.   +21 more
europepmc   +1 more source

Publisher Correction: Descriptive Analysis of Good Clinical Practice Inspection Findings from U.S. Food and Drug Administration and European Medicines Agency. [PDF]

Ther Innov Regul Sci, 2022
Sellers JW, Mihaescu CM, Ayalew K, Kronstein PD, Yu B, Ning YM, Rodriguez M, Williams L, Khin NA.   +8 more
europepmc   +1 more source

SIOG guidelines- essential for good clinical practice in geriatric oncology [PDF]

, 2019
Roman Dubiański, Tanya M. Wildes, Hans Wildiers   +2 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Monitoring of invasive assisted mechanical ventilation: a good clinical practice document by the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI). [PDF]

J Anesth Analg Crit Care
Colombo D, Ippolito M, Bellani G, Battaglini D, Cammarota G, Cortegiani A, Giarratano A, Grasso S, Maggiore SM, Mirabella L, Navalesi P, Rauseo M, Simonte R, Spadaro S, Spinazzola G, Grasselli G.   +15 more
europepmc   +1 more source

Development of a Good Clinical Practice inspection checklist to assess clinical trial sites in Vietnam. [PDF]

BMJ Open, 2021
Nguyen QN, Nguyen NV, Nguyen DTP, Vidaillac C, Trinh PTM, van Doorn HR, Thwaites GE, Kestelyn E, Vo HTN.   +8 more
europepmc   +1 more source

Estimating Health-State Utility for Economic Models in Clinical Studies: An ISPOR Good Research Practices Task Force Report [PDF]

, 2016
Sorrel Wolowacz, Andrew Briggs, Vasily Belozeroff, Philip Clarke, Lynda Doward, Ron Goeree, Andrew Lloyd, Richard Norman   +7 more
openalex   +1 more source