Results 71 to 80 of about 376,667 (303)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A Simple Method for Testing Independence of High-Dimensional Random Vectors
Austrian Journal of Statistics, 2016 A simple, data-driven and computationally efficient procedure for testing independence of high-dimensional random vectors is proposed. The procedure is based on interpretation of testing goodness-of-fit as the classification problem, a special sequential
Gintautas Jakimauskas +2 more
doaj +1 more source
, 2015 In this paper new two-dimensional goodness of fit tests are proposed. They are of supremum-type and are based on different types of characterizations. For the first time a characterization based on independence of two statistics is used for goodness-of ...
Milošević, Bojana, Obradović, Marko
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Construction of a geographically weighted nonparametric regression model fit test
MethodsXOne of the approach of Geographically Weighted Regression (GWR) models is the Geographically Weighted Nonparametric Regression (GWNR) has more parameters than the GWR model.
Lilis Laome +2 more
doaj +1 more source
Mathematics, 2019 We have been attempting to evaluate software quality and improve its reliability. Therefore, research on a software reliability model was part of the effort.
Kwang Yoon Song +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Robustness of the Trinormal ROC Surface Model: Formal Assessment via Goodness-of-Fit Testing
StatsReceiver operating characteristic (ROC) surfaces provide a natural extension of ROC curves to three-class diagnostic problems. A key summary index is the volume under the surface (VUS), representing the probability that a randomly chosen observation from
Christos Nakas
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Multivariate goodness-of-fit tests based on kernel density estimators
Nonlinear Analysis, 2015 The paper is devoted to multivariate goodness-of-fit ests based on kernel density estimators. Both simple and composite null hypotheses are investigated.
Aleksej Bakshaev, Rimantas Rudzkis
doaj +1 more source