Results 31 to 40 of about 14,277 (262)

Isolation and characterization of a novel gossypol-degrading bacteria strain Rumen Bacillus Subtilis [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The aim of the study was to isolate gossypol-degrading bacteria and to assess its potential for gossypol degradation. Methods Rumen liquid was collected from fistulated cows grazing the experimental pasture.
Yunhua Zhang, Zhengyou Zhang, Li Dai, Ying Liu, Maoji Cheng, Lijuan Chen   +5 more
doaj   +1 more source

Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

Pharmaceuticals, 2022
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms.
Mascha Mayer, Alexander Berger, Christian Leischner, Olga Renner, Markus Burkard, Alexander Böcker, Seema Noor, Timo Weiland, Thomas S. Weiss, Christian Busch, Ulrich M. Lauer, Stephan C. Bischoff, Sascha Venturelli   +12 more
doaj   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

Seasonal Dietary Patterns of Tarim Red Deer (<i>Cervus hanglu yarkandensis</i>) Revealed by the <i>trnL</i> Sequencing Approach in the Tarim River Basin (Xinjiang, China). [PDF]

Ecol Evol
This study employed DNA metabarcoding technology to analyze the seasonal dietary habits of Tarim red deer in Xinjiang within a mixed habitat of Populus euphratica and cotton. Results indicate a primary reliance on cotton (38.75%) and European poplar (36.87%). Summer dietary diversity and ecological niche breadth were significantly higher than in winter
Qi C, Tian X, Cui Y, Zhu L, Focardi S, Zhong L.   +5 more
europepmc   +2 more sources

Plant Polyphenol Gossypol Induced Cell Death and Its Association with Gene Expression in Mouse Macrophages

Biomolecules, 2023
Gossypol is a complex plant polyphenol reported to be cytotoxic and anti-inflammatory, but little is known about its effect on gene expression in macrophages.
Heping Cao, Kandan Sethumadhavan
doaj   +1 more source

Metabolomic Profiling and Network Toxicology: Mechanistic Insights into Effect of Gossypol Acetate Isomers in Uterine Fibroids and Liver Injury

Pharmaceuticals
Objective: Gossypol is a natural polyphenolic dialdehyde product that is primarily isolated from cottonseed. It is a racemized mixture of (−)-gossypol and (+)-gossypol that has anti-infection, antimalarial, antiviral, antifertility, antitumor and ...
Zishuo Liu, Hui Zhang, Jun Yao
doaj   +1 more source

Biodegradation of Free Gossypol by Helicoverpa armigera Carboxylesterase Expressed in Pichia pastoris

Toxins, 2022
Gossypol is a polyphenolic toxic secondary metabolite derived from cotton. Free gossypol in cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of gossypol produces metabolites that reduce feed quality.
Li Zhang, Xiaolong Yang, Rongzheng Huang, Cunxi Nie, Junli Niu, Cheng Chen, Wenju Zhang   +6 more
doaj   +1 more source

Gossypol Toxicity from Cottonseed Products

The Scientific World Journal, 2014
Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins.
Ivana Cristina N. Gadelha, Nayanna Brunna S. Fonseca, Silvia Catarina S. Oloris, Marília M. Melo, Benito Soto-Blanco   +4 more
doaj   +1 more source

Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

Biological Research, 2015
BACKGROUND: Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals.
Andréia T Santana, Marieli Guelfi, Hyllana C D Medeiros, Marco A Tavares, Paulo F V Bizerra, Fábio E Mingatto   +5 more
doaj   +1 more source

Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters [PDF]

, 2019
Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities.
Costantino, Andrea Rosana, Koll, Liliana Cristina, Mandolesi, Sandra Delia, Neudörfl, Jörg M., Ocampo, Romina Andrea, Svetaz, Laura Andrea, Zacchino, Susana Alicia Stella   +6 more
core   +1 more source