Results 31 to 40 of about 14,284 (259)

Conformational analysis of gossypol and its derivatives by molecular mechanics [PDF]

open access: yes, 2005
Conformations and inversion pathways leading to racemization of all the tautomers of gossypol, gossypolone, anhydrogossypol, and a diethylamine Schiff\u27s base of gossypol were investigated with MM3(2000).
Beisel, Chase   +3 more
core   +3 more sources

Gossypol and Its Natural Derivatives: Multitargeted Phytochemicals as Potential Drug Candidates for Oncologic Diseases

open access: yesPharmaceutics, 2022
Despite the vast amounts of research and remarkable discoveries that have been made in recent decades, cancer remains a leading cause of death and a major public health concern worldwide.
Dilipkumar Pal   +4 more
doaj   +1 more source

Small molecule and peptide inhibitors of the pro-survival protein Mcl-1 [PDF]

open access: yes, 2016
The ability of protein–protein interactions to regulate cellular processes in both beneficial and detrimental ways has made them obvious drug targets.
Beekman, Andrew, Howell, Lesley
core   +1 more source

Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells

open access: yesScientific Reports, 2021
Plant polyphenol gossypol has anticancer activities. This may increase cottonseed value by using gossypol as a health intervention agent. It is necessary to understand its molecular mechanisms before human consumption.
Heping Cao   +3 more
doaj   +1 more source

Seminal Plasma Proteins [PDF]

open access: yes, 2012
The ejaculated semen consists of two major components viz. sperm cells (spermatozoa) and the fluid part obtained after centrifugation called seminal plasma.
P Perumal
core   +2 more sources

Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters [PDF]

open access: yes, 2019
Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities.
Costantino, Andrea Rosana   +6 more
core   +1 more source

Isolation and characterization of a novel gossypol-degrading bacteria strain Rumen Bacillus Subtilis [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2018
Objective The aim of the study was to isolate gossypol-degrading bacteria and to assess its potential for gossypol degradation. Methods Rumen liquid was collected from fistulated cows grazing the experimental pasture.
Yunhua Zhang   +5 more
doaj   +1 more source

Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

open access: yesPharmaceuticals, 2022
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms.
Mascha Mayer   +12 more
doaj   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

open access: yes, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan   +1 more
core   +2 more sources

Plant Polyphenol Gossypol Induced Cell Death and Its Association with Gene Expression in Mouse Macrophages

open access: yesBiomolecules, 2023
Gossypol is a complex plant polyphenol reported to be cytotoxic and anti-inflammatory, but little is known about its effect on gene expression in macrophages.
Heping Cao, Kandan Sethumadhavan
doaj   +1 more source

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