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INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +6 more sources
Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in articular and non-articular structures. Increased concentration of serum urate (hyperuricaemia) is the most important risk factor for the development of gout.
Kwok, Timothy S.H.+2 more
openaire +4 more sources
Background Gout is a common and debilitating condition that is associated with significant morbidity and mortality. Despite advances in medical treatment, the global burden of gout continues to increase, particularly in high–sociodemographic index (SDI ...
Qiyu He+7 more
semanticscholar +1 more source
To the Editor: The Clinical Practice review on gout by Mikuls (Nov. 17 issue)1 underscores the importance of hyperuricemia as a necessary risk factor and mentions the high heritability of serum urate levels.2 Serum urate levels are mostly controlled by the kidney, as confirmed by genetic studies implicating both rare and common variants in transporters
Devuyst, Olivier+2 more
openaire +4 more sources
Trends in Prevalence of Gout Among US Asian Adults, 2011-2018
Key Points Question Does the prevalence of gout differ between Asian and White adults in the US, and are social and clinical factors associated with the variation?
C. Yokose+12 more
semanticscholar +1 more source
Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition. Gout typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints of the lower limb. Elevated serum urate level (hyperuricaemia) is the major risk factor for MSU crystal deposition and development of gout. Although traditionally considered
Dalbeth, N.+6 more
+8 more sources
Objective To use data from the Global Burden of Disease (GBD) Study 2019 to report the global, regional and national rates and trends of annual incidence, point prevalence and years lived with disability (YLD) for gout in adolescents and young adults ...
Jing Zhang+8 more
semanticscholar +1 more source
Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout.
Importance Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated.
E. Cipolletta+5 more
semanticscholar +1 more source
Key Points Question What is the association between using sodium-glucose contransporter-2 inhibitors (SGLT2i) and the risk of recurrent gout flares among adults with gout and type 2 diabetes?
Jie Wei+7 more
semanticscholar +1 more source
Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a ...
Zhilei Wang+6 more
semanticscholar +1 more source