Results 21 to 30 of about 157,164 (243)

The first metatarsophalangeal joint in gout: a systematic review and meta analysis [PDF]

, 2016
Background: The aim of this review was to qualitatively synthesise studies that have investigated characteristics of the first metatarsophalangeal joint (1st MTP) in gout and to undertake a meta-analysis to estimate the average prevalence of acute 1st ...
Dalbeth, N, Rome, K, Stewart, S, Vandal, AC   +3 more
core   +2 more sources

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders.
Quan-Bo Zhang, Quan-Bo Zhang, Dan Zhu, Dan Zhu, Dan Zhu, Fei Dai, Fei Dai, Yu-Qin Huang, Yu-Qin Huang, Jian-Xiong Zheng, Jian-Xiong Zheng, Yi-Ping Tang, Yi-Ping Tang, Zeng-Rong Dong, Zeng-Rong Dong, Xia Liao, Xia Liao, Yu-Feng Qing, Yu-Feng Qing   +18 more
doaj   +1 more source

Identification of a Novel Mutation in a Pseudohypoparathyroidism Family

International Journal of Endocrinology, 2011
Pseudohypoparathyroidism type Ia (PHP Ia) is defined as a series of disorders characterized by multihormone resistance in end-organs and Albright hereditary osteodystrophy (AHO) phenotype.
Zhi-Min Miao, Can Wang, Bin-Bin Wang, Dong-Mei Meng, Dong-Mei Su, Zhi Cheng, Qiao-Lian Wen, Lin Han, Qing Yu, Xu Ma, Chang-Gui Li   +10 more
doaj   +1 more source

Food oral processing in humans: links between physiological parameters, release of flavour stimuli and flavour perception of food

International Journal of Food Studies, 2018
In humans, food oral processing (FOP) is the first step in the digestive process. It prepares the food for swallowing and to undergo the process of digestion.
Gilles Feron, Christian Salles
doaj   +1 more source

First validation of the gout activity score against gout impact scale in a primary care based gout cohort [PDF]

, 2017
Objectives To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. Methods This was a single-centre cross-sectional study.
Abhishek, Abhishek, Doherty, Michael, Fernandes, Gwen Sascha, Jenkins, Wendy, La-Crette, Jonathan, Valdes, Ana M.   +5 more
core   +2 more sources

Provably Good Solutions to the Knapsack Problem via Neural Networks of Bounded Size [PDF]

, 2021
The development of a satisfying and rigorous mathematical understanding of the performance of neural networks is a major challenge in artificial intelligence.
Hertrich, Christoph, Skutella, Martin
core   +3 more sources

Gout Storm

American Journal of Case Reports, 2021
BACKGROUND Gout is a chronic disease characterized by deposition of monosodium urate crystals, typically manifesting as arthritis. Clinical presentation of gout usually results from activation of local inflammatory response. Despite being one of the oldest diseases in the world, gout pathophysiology is incompletely understood and clinical features are ...
Martins, Danilo, Tonon, Carolina Rodrigues, Pacca, Rafael Lopes, Matchil, Natanye Lemes, Junior, Luiz Antonio Jorge, Queiroz, Dênis Silva, Pereira, Filipe Welson Leal, Silva, Alana Maia, Padovese, Vinicius, De Toledo Moraes, Marcelo Padovani, Da Silva, Daniel Luiz, Nóbrega, Vinicius Cardoso, Curcelli, Emilio Carlos, Okoshi, Marina Politi   +13 more
openaire   +4 more sources

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

Oncogenesis, 2022
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma, Xiaoxiao Ma, Lihui Zhu, Yunxue Zhao, Mengmeng Chen, Tao Li, Yueke Lin, Dapeng Ma, Caiyu Sun, Lihui Han   +9 more
doaj   +1 more source

The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study

Frontiers in Medicine, 2022
ObjectiveInterstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) that manifests as several subtypes with significant differences in prognosis.
Jiaqi Wang, Jiaqi Wang, Xiao Wang, Xiao Wang, Xiaoyan Qi, Xiaoyan Qi, Zhijian Sun, Zhijian Sun, Tao Zhang, Yi Cui, Qiang Shu, Qiang Shu   +11 more
doaj   +1 more source

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan [PDF]

, 2015
OBJECTIVE: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population.
Ab. Usbott, Adamopoulos, Ana M Valdes, Annemans, Arromdee, Bhole, Blumberg, Cea Soriano, Chang-Fu Kuo, Choi, Choi, Choi, Choi, Choi, Choi, Chou, Cobb, Copeman, De Souza, Dehghan, Edwards, Emmerson, Falconer, Grahame, Hak, Hauge, Hueskes, Kolz, Kottgen, Krishnan, Krishnan, Krishnan, Kuang-Hui Yu, Kuo, Lai-Chu See, Lee, Lin, Lin, Lin, Matthew J Grainge, Michael Doherty, Mikuls, Mikuls, Mituszova, Ober, Reginato, Reich, Reich, Rice, Risch, Sheane, Shue-Fen Luo, Smyth, Smyth, Vitart, Wang, Weiya Zhang, Wilk, Winnard, Wray, Wu, Zhu   +61 more
core   +1 more source