Results 1 to 10 of about 911 (123)
Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage [PDF]
Molecules, 2021 Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues. The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators. Therefore, we decided to search for a small-molecule inhibitor of the NLRP3 inflammasome for the prevention of gout ...
Nuri Choi +6 more
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A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression [PDF]
Frontiers in Pharmacology, 2021 Background: Activation of nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in gout. Selaginella moellendorffii has been confirmed effective for the treatment of gout in hospital preparations. Flavonoids, such as amentoflavone (AM), are the main active components of this medicine.Purpose: We aimed to ...
Xueyan Zhang +7 more
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Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression [PDF]
Journal of Neuroinflammation, 2017 Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-
Hai-Jiao Liu +9 more
openaire +3 more sources
Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis [PDF]
Molecules, 2019 Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the gout inflammatory symptoms induced by MSU crystals.
Hye Eun Lee +6 more
openaire +3 more sources
Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways [PDF]
International Journal of Molecular Sciences, 2019 Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections.
Yu Wang +5 more
openaire +2 more sources
Uso de corticoides sistémicos no tratamento da artrite gotosa aguda: qual a evidência?
Revista Portuguesa de Medicina Geral e Familiar, 2019 Objetivo: Avaliar a eficácia dos corticóides sistémicos (CS) no tratamento da artrite gotosa aguda (AGA) e os seus benefícios face às terapêuticas clássicas nomeadamente a colchicina e os anti-inflamatórios não esteroides (AINEs).
Ana Margarida Costa +1 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Abstract Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering therapy (ULT) titration to target, we performed a prospective study of ...
Monica Guma +11 more
openaire +7 more sources
AB0084 Elevated levels of il-37 are associated with tophus and suppressed the production of inflammatory cytokines in patients with gout [PDF]
Annals of the Rheumatic Diseases, 2018 Background IL-37 has been identified as a natural inhibitor of innate immunity. Although increasing evidence shows elevated IL-37 expression in various autoimmune diseases, its correlation with clinical symptoms in gout is still unclear. Objectives This study aims to determine the correlation between the levels of IL-37 and clinical indexes in gout ...
X. Hong, L. Ding, Q. Huang, D. Liu
openaire +1 more source
AB0074 Daily exercise suppresses acute pro-inflammatory cytokine expression systemically and il-1Β locally in a murine model of gout [PDF]
Annals of the Rheumatic Diseases, 2018 Background Recent gout clinical practice recommendations/guidelines released by the ACR (2012) and the ACP (2017) do not address exercise as an interventional strategy; in contrast, the 2016 EULAR gout recommendations suggest that regular physical activity might decrease the excess mortality associated with chronic hyperuricemia.
N.A. Young +7 more
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, 2022 Additional file 1: Supplementary Figure 1. PLS-DA and RF analysis of serum metabolomic profiling at time zero. PLS-DA and RF analysis at time zero resulted in a good discrimination and prediction of the samples per BMI (A), but not per number of flares (B), or hyperuricemia (HU) > 8 mg/dL (C), or presence of tophi (D). Supplementary Figure 2.
Guma, Monica +11 more
openaire +1 more source