Results 1 to 10 of about 282 (63)

Do proton pump inhibitors increase the risk of dementia? A systematic review, meta‐analysis and bias analysis [PDF]

open access: yesBritish Journal of Clinical Pharmacology, Volume 89, Issue 2, Page 602-616, February 2023., 2022
AimPrevious studies on the association between proton pump inhibitor (PPI) intake and the increased risk of dementia has shown discrepancies in their conclusions.
Ahn, Nayeon   +10 more
core   +3 more sources

Changes in multimorbidity and polypharmacy patterns in young and adult population over a 4-year period: A 2011–2015 comparison using real-world data [PDF]

open access: yes, 2021
The pressing problem of multimorbidity and polypharmacy is aggravated by the lack of specific care models for this population. We aimed to investigate the evolution of multimorbidity and polypharmacy patterns in a given population over a 4-year period ...
Aza-Pascual-salcedo M.   +10 more
core   +1 more source

Prediction of renal and cardiometabolic outcomes in gout during urate‐lowering therapy by sonography

open access: yesInternational Journal of Rheumatic Diseases, Volume 26, Issue 12, Page 2450-2459, December 2023., 2023
Abstract Objectives To assess whether the extent of monosodium urate (MSU) crystal deposition estimated by ultrasound could predict renal and cardiometabolic events during urate‐lowering therapy (ULT). Methods A prospective study on gout patients from two referral centers initiating ULT who underwent baseline ultrasound and were followed for 1 year ...
Irene Calabuig   +7 more
wiley   +1 more source

Prescribing cascades in community‐dwelling adults: A systematic review

open access: yesPharmacology Research &Perspectives, Volume 10, Issue 5, October 2022., 2022
Prescribing cascades in community dwelling adults: Systematic review. Abstract The misattribution of an adverse drug reaction (ADR) as a symptom or illness can lead to the prescribing of additional medication, referred to as a prescribing cascade. The aim of this systematic review is to identify published prescribing cascades in community‐dwelling ...
Ann S. Doherty   +8 more
wiley   +1 more source

siRNA‐based nanotherapeutics as emerging modalities for immune‐mediated diseases: A preliminary review

open access: yesCell Biology International, Volume 46, Issue 9, Page 1320-1344, September 2022., 2022
Abstract Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated etiology. Clinically, these diseases appear to be unrelated, but pathogenic pathways have been shown to connect them. While inflammation is a common occurrence in the body, it may either stimulate a favorable immune response to protect against harmful signals ...
Saman Sargazi   +8 more
wiley   +1 more source

Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator

open access: yesClinical and Translational Science, Volume 15, Issue 2, Page 548-557, February 2022., 2022
Abstract Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI) on dorzagliatin’s pharmacokinetics (PKs) and safety, and to guide appropriate clinical ...
Jia Miao   +16 more
wiley   +1 more source

Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID‐19

open access: yesInternational Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022
The COVID‐19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease.
Viktor Kamkin   +6 more
wiley   +1 more source

Self‐reported medication intake vs information from other data sources such as pharmacy records or medical records: Identification and description of existing publications, and comparison of agreement results for publications focusing on patients with cancer ‐ a systematic review

open access: yesPharmacoepidemiology and Drug Safety, Volume 30, Issue 5, Page 531-560, May 2021., 2021
Abstract Purpose To identify and describe publications addressing the agreement between self‐reported medication and other data sources among adults and, in a subgroup of studies dealing with cancer patients, seek to identify parameters which are associated with agreement. Methods A systematic review including a systematic search within five biomedical
Manuela Brüne   +7 more
wiley   +1 more source

Direct healthcare professional communications: A quantitative assessment study

open access: yesPharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Abstract A retrospective observational study evaluated the direct healthcare professional communication (DHPC) letters disseminated by the Saudi Food and Drug Authority (SFDA) and their compliance with the pharmacovigilance guidelines. The study was utilized all DHPC letters available on the SFDA website, which is intended to communicate drug safety ...
Hajar Alsaleh, Thamir M. Alshammari
wiley   +1 more source

Combinatory Effects of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant‐Induced Arthritis in Wistar Rats: Roles of IL‐1β, IL‐4, Nrf‐2, and Oxidative Stress

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with chronic inflammation and severe disability. Bone Marrow‐derived Mesenchymal Stem Cells (BM‐MSCs) have shown a hopeful immunomodulatory effect towards repairing cartilage and restoring joint function.
Eman A. Ahmed   +7 more
wiley   +1 more source

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