Results 141 to 150 of about 1,194 (166)

Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Acta Pharmacologica Sinica
Abnormal activation of NLRP3 inflammasome causes the progression of gout, and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use. In this study we established a nigericin-induced inflammasome activation cell model for screening of a natural product library by measuring IL-1β secretion in cell supernatants.
Le-Jin, Yan, Shuang, Qi, Chao, Wu, Rui, Jin, Chen, Hu, Ao-Li, Wang, Bei-Lei, Wang, Hong-Wei, Yu, Li, Wang, Jing, Liu, Zi-Ping, Qi, Wen-Chao, Wang, Qing-Song, Liu   +12 more
openaire   +2 more sources

Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response

Food & Function
Limonin restored UA homeostasis by simultaneously regulating UA excretion and production. It alleviated hepatorenal damage and inflammation by binding to AMPK, thereby suppressing downstream inflammatory activation.
Minjie Zeng, Mei Zhong, Xiaomei Zhong, Yiqian Zhang, Xueting Chen, Jing Lin, Ying Zhang, Yanfang Zheng, Jinjian Lu, Mingqing Huang   +9 more
openaire   +1 more source

How effective is allopurinol at suppressing recurrent gout attacks?

Evidence-Based Practice, 2016
Jennifer Cook, Annika Maly, Jaime Palmer, Justin Bailey   +3 more
openaire   +1 more source

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors

Nature Reviews Rheumatology, 2020
Mats Dehlin, Lennart T H Jacobsson, Edward Roddy   +2 more
exaly  

Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care

Nature Reviews Rheumatology, 2021
Hyon K Choi, Natalie McCormick, Chio Yokose   +2 more
exaly  

Global epidemiology of gout: prevalence, incidence and risk factors

Nature Reviews Rheumatology, 2015
Chang-Fu Kuo, Matthew J Grainge, Weiya Zhang   +2 more
exaly  

Inflammation in gout: mechanisms and therapeutic targets

Nature Reviews Rheumatology, 2017
Fabio Martinon
exaly  

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Nature Genetics, 2008
Veronique Vitart, Igor D Rudan, Caroline Hayward   +2 more
exaly  

An update on the genetics of hyperuricaemia and gout

Nature Reviews Rheumatology, 2018
Nicola Dalbeth, Fracp, Eli A Stahl, Tony R Merriman   +2 more
exaly  

Uric acid as a danger signal in gout and its comorbidities

Nature Reviews Rheumatology, 2012
Kenneth L Rock, Hiroshi Kataoka
exaly