Results 31 to 40 of about 9,244 (205)
Role of microRNA alternation in the pathogenesis of gouty arthritis
Frontiers in Endocrinology, 2022 Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares.
Zhipan Luo +27 more
doaj +1 more source
Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout
Arthritis Care &Research, EarlyView.Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi +27 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang +4 more
wiley +1 more source
Therapeutic Effect of Polygonum multiflorum Extract on Gouty Arthritis in Rats [PDF]
BIO Web of ConferencesObjective: The investigation of the efficacy of Polygonum multiflorum extract on gouty arthritis in rats. Method: Thirty male SD rats were randomly divided into blank control group, gouty arthritis model group, colchicine group, low, medium, and high ...
Tan Jinyi, Liu Qihang, He Lian
doaj +1 more source
Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis
BMC Musculoskeletal Disorders, 2023 Objective The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle ...
Ruiting Zhu +9 more
doaj +1 more source
Bilateral Gouty Arthritis Developing After Covid-19 Infection: A Case Report
Turkish Journal of Internal Medicine, 2022 Introduction and Purpose: SARS-CoV-2 virus started in Wuhan, China in 2019 and caused the COVID-19 pandemic by affecting the whole world in a short time. Arthralgia is one of the symptoms that can be seen after Covid-19 infection and can be seen in 14.9%
Şeyma Handan Akyön +1 more
doaj +1 more source
Advanced Science, EarlyView.A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang +14 more
wiley +1 more source
Molecular Pain, 2021 Lack of uricase leads to the high incidence of gout in humans and poultry, which is different from rodents. Therefore, chicken is considered to be one of the ideal animal models for the study of gout. Gout-related pain caused by the accumulation of urate
Ren-Hao Liu +4 more
doaj +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source