Results 61 to 70 of about 2,006,808 (290)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Investigating the role of government trade policies and regulations on smuggling cosmetic products [PDF]

Management Science Letters, 2014
This paper investigates the effects of government trade policies as well as the rules and regulations on smuggling cosmetic products in Iran. The study considers the effects of five important factors including high tariffs and bureaucratic procedures ...
Sahar Seifpoor, Reza Agha Mousa
doaj   +1 more source

A Report on the Media and the Immigration Debate [PDF]

, 2008
Analyzes media coverage of immigration since 1980 and how industry practices and new media have conditioned the public to associate immigration with illegality, crisis, controversy, and government failure, causing a stalemate in the policy ...
Banu Akdenizli, E. J. Dionne, Jr., Martin Kaplan, Roberto Suro, Tom Rosenstiel   +4 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Participación pública y privada en la provisión de servicios de salud, Colombia 2006 Public and private participation in Health Services provision in Colombia 2006

Investigación y Educación en Enfermería, 2007
Objetivo: Este artículo pretende aportar al debate sobre la participación pública y privada en la provisión de servicios de salud y discutir los aspectos principales de las reformas de salud en Colombia en el contexto internacional y algunos de sus ...
Gloria Molina M, Claudia Milena Rodríguez T   +1 more
doaj  

Government Failure in Urban Transportation [PDF]

This paper assesses governmental performance in its investment, provision and regulation of urban transportation. Attention is given to public bus and rail transit and road transportation.
Clifford Winston
core  

A Better Way to Generate and Use Comparative-Effectiveness Research [PDF]

, 2009
President Barack Obama, former U.S. Senate majority leader Tom Daschle, and others propose a new government agency that would evaluate the relative effectiveness of medical treatments. The need for "comparative-effectiveness research" is great.
Michael F. Cannon
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Newt Gingrich's Remarks from the AEI-Brookings Joint Center Event: "Markets vs. Government" [PDF]

Newt Gingrich discussed Clifford Winston's book, Government Failure vs. Market Failure: Microeconomics Policy Research and Government Performance , at an AEI-Brookings Joint Center event held on May 4, 2007.Regulatory ...
Gingrich, Newt
core   +1 more source