Immunomagnetic Sample Preparation Targeting Host- and Viral-Derived Antigens for HIV-1 Isolation from Limited Plasma Volumes. [PDF]
Gulati GK +3 more
europepmc +1 more source
Exploring the impact of baseline and on-treatment variables on durability of responses to fostemsavir through weeks 96 and 192 in the phase 3 BRIGHTE study. [PDF]
Gartland M +8 more
europepmc +1 more source
DNA electroporation of HIV Env elicits robust T cell responses and memory B cell responses with muted serum antibody levels that can be boosted with recombinant protein. [PDF]
De Rosa SC +30 more
europepmc +1 more source
mGem: Opening Env and harnessing NK cell effector functions to eliminate HIV-1-infected cells. [PDF]
Richard J, Finzi A.
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GP120: Biologic Aspects of Structural Features
Annual Review of Immunology, 2001▪ Abstract HIV-1 particles are decorated with a network of densely arranged envelope spikes on their surface. Each spike is formed of a trimer of heterodimers of the gp120 surface and the gp41 transmembrane glycoproteins. These molecules mediate HIV-1 entry into target cells, initiating the HIV-1 replication cycle.
Pascal Poignard +2 more
exaly +3 more sources
HIV-1 gp120 dimers decrease the overall affinity of gp120 preparations for CD4-induced ligands
Journal of Virological Methods, 2015For several years, tools to study the conformational changes of HIV-1 envelope glycoproteins have been developed in order to comprehend those changes and their role in the fusion process and immunogenicity of HIV-1. To facilitate these studies, expression of the HIV-1 gp120 envelope glycoprotein has been done in several over-expression settings ...
Mathieu Coutu, Andres Finzi
exaly +3 more sources
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
openaire +2 more sources
Correlated mutations at gp120 positions 322 and 440: Implications for gp120 structure
Proteins: Structure, Function, and Bioinformatics, 2008AbstractAnalysis of V3 and C4 sequences of HIV‐1 reveals correlated mutations at gp120 positions 322 and 440, and a very strong preference for a positively charged residue at position 440 when position 322 is negatively charged. This observation suggests that these two residues are close to each other and interact electrostatically in R5 viruses.
Osnat, Rosen +2 more
openaire +2 more sources
HIV-1 gp120 AND IMMUNE NETWORK
International Reviews of Immunology, 2004It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune ...
Radmila, Metlas, Veljko, Veljkovic
openaire +2 more sources
gp120 neurotoxicity in primary cortical cultures
Advances in Neuroimmunology, 1994The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists.
T M, Dawson, V L, Dawson
openaire +2 more sources

