Results 141 to 150 of about 24,116 (179)
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Nitric Oxide Production and Apoptosis by GP120
Allergy and Asthma Proceedings, 2000Nitric oxide (NO) is increased by gp120 in astrocytes and in monocyte-derived macrophages. Of the gp120 fragments (F1: amino acid 254-274, F2: amino acid 315-329, F3: amino acid 421-438), F1 has been shown to increase NO in astrocytes and gp120 also primes CD4+ T cells for apoptosis.
A, Mansur +3 more
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Circulating gp120 alters the blood–brain barrier permeability in HIV-1 gp120 transgenic mice
Neuroscience Letters, 2002The mechanism underlying invasion of the central nervous system by HIV-1 is unclear. We recently demonstrated blood-brain barrier changes in a model of HIV-1 gp120 transgenic mice. To test whether this alteration was intrinsic to the brain endothelium of transgenic mice or depended on circulating gp120, we used brain endothelial cultures from gp120 ...
CIONI C., ANNUNZIATA P.
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Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation
Science, 1989The human immunodeficiency virus (HIV) binds to CD4-positive cells through interaction of its envelope glycoprotein (gp120) with the CD4 molecule. CD4 is a prominent immunoregulatory molecule, and chronic exposure to antibody against CD4 (anti-CD4) has been shown to cause immunodeficiency in mice. T cell-dependent in vitro immune responses
R S, Mittler, M K, Hoffmann
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Trends in Microbiology, 1998
When HIV-infected patients progress to AIDS, there is not only a drop in CD4 T-cell numbers but also an appreciable decline in CD8 T-cell populations. To determine if the depletion of CD8 T cells can be mediated directly by HIV, Herbein et al., 1998xApoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine ...
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When HIV-infected patients progress to AIDS, there is not only a drop in CD4 T-cell numbers but also an appreciable decline in CD8 T-cell populations. To determine if the depletion of CD8 T cells can be mediated directly by HIV, Herbein et al., 1998xApoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine ...
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Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1997
A synthetic peptide resembling the C2 region of human immunodeficiency virus type 1 (HIV-1) gp120 (C2-Lai: amino acids (aa) 273-288), inhibited (C50 = 200 microM) gp120 calcium-dependent binding of N-acetyl-beta-D-glucosaminyl and mannosyl residues exposed on natural glycoprotein bovine fetuin whereas a peptide derived from an aa sequence downstream of
N, Seddiki +6 more
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A synthetic peptide resembling the C2 region of human immunodeficiency virus type 1 (HIV-1) gp120 (C2-Lai: amino acids (aa) 273-288), inhibited (C50 = 200 microM) gp120 calcium-dependent binding of N-acetyl-beta-D-glucosaminyl and mannosyl residues exposed on natural glycoprotein bovine fetuin whereas a peptide derived from an aa sequence downstream of
N, Seddiki +6 more
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Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.
The Journal of Immunology, 1989Abstract The HIV envelope glycoprotein gp120 binds with high affinity to CD4 and is responsible for the tropism of HIV for CD4+ T cells and monocytes. Efforts to develop HIV vaccines have focused on gp120 and, therefore, a detailed molecular understanding of human immune responses to gp120 is essential. In this report, we have used human
R F, Siliciano +5 more
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gp120 and neurotoxicity in vivo
Trends in Pharmacological Sciences, 1995S A, Lipton +4 more
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2019
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NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
Cellular and Molecular Immunology, 2019Xiaolong He, Zhijie Zeng, Bao Zhang
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