The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC. [PDF]
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Evolving rare B cell lineages for an effective HIV vaccine. [PDF]
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Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase. [PDF]
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Crystal structure of HERV-K envelope glycoprotein surface subunit
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GP120: Biologic Aspects of Structural Features
Annual Review of Immunology, 2001▪ Abstract HIV-1 particles are decorated with a network of densely arranged envelope spikes on their surface. Each spike is formed of a trimer of heterodimers of the gp120 surface and the gp41 transmembrane glycoproteins. These molecules mediate HIV-1 entry into target cells, initiating the HIV-1 replication cycle.
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