Results 171 to 180 of about 48,162 (201)
Engineered Delivery Systems for Chinese Herbal Medicine in Peripheral Nerve Regeneration: Challenges, Advances, and Future Perspectives. [PDF]
Drug Des Devel TherZhang R, Gu M, Ma R, Li R, Xu S, Xu Z.
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Current Opinion in Immunology, 1991
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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Correlated mutations at gp120 positions 322 and 440: Implications for gp120 structure
Proteins: Structure, Function, and Bioinformatics, 2008AbstractAnalysis of V3 and C4 sequences of HIV‐1 reveals correlated mutations at gp120 positions 322 and 440, and a very strong preference for a positively charged residue at position 440 when position 322 is negatively charged. This observation suggests that these two residues are close to each other and interact electrostatically in R5 viruses.
Osnat, Rosen +2 more
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Circulating gp120 alters the blood–brain barrier permeability in HIV-1 gp120 transgenic mice
Neuroscience Letters, 2002The mechanism underlying invasion of the central nervous system by HIV-1 is unclear. We recently demonstrated blood-brain barrier changes in a model of HIV-1 gp120 transgenic mice. To test whether this alteration was intrinsic to the brain endothelium of transgenic mice or depended on circulating gp120, we used brain endothelial cultures from gp120 ...
CIONI C., ANNUNZIATA P.
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Trends in Microbiology, 1998
When HIV-infected patients progress to AIDS, there is not only a drop in CD4 T-cell numbers but also an appreciable decline in CD8 T-cell populations. To determine if the depletion of CD8 T cells can be mediated directly by HIV, Herbein et al., 1998xApoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine ...
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When HIV-infected patients progress to AIDS, there is not only a drop in CD4 T-cell numbers but also an appreciable decline in CD8 T-cell populations. To determine if the depletion of CD8 T cells can be mediated directly by HIV, Herbein et al., 1998xApoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine ...
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GP120: Biologic Aspects of Structural Features
Annual Review of Immunology, 2001▪ Abstract HIV-1 particles are decorated with a network of densely arranged envelope spikes on their surface. Each spike is formed of a trimer of heterodimers of the gp120 surface and the gp41 transmembrane glycoproteins. These molecules mediate HIV-1 entry into target cells, initiating the HIV-1 replication cycle.
P, Poignard +3 more
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Lithium Ameliorates HIV-gp120-Mediated Neurotoxicity
Molecular and Cellular Neuroscience, 2002To investigate the protective effects of lithium against HIV-gp120-mediated toxicity in vivo, mice were exposed to lithium and gp120 and levels of the neuronal markers, microtubule-associated protein-2 and NeuN, and the astrocyte marker, glial fibrillary acidic protein, were determined.
Everall, I P +6 more
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HIV-1 gp120 AND IMMUNE NETWORK
International Reviews of Immunology, 2004It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune ...
Radmila, Metlas, Veljko, Veljkovic
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