Results 141 to 150 of about 61,419 (246)

Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets

, 2006
Paul A. Insel, Chih‐Min Tang, Ines N. Hahntow, Martin C. Michel   +3 more
openalex   +1 more source

Manifold active‐state conformations in GPCRs: Agonist‐activated constitutively active mutant AT₁ receptor preferentially couples to Gq compared to the wild‐type AT₁ receptor [PDF]

, 2007
ChangWoo Lee, Si Ae Hwang, Sei-Heon Jang, Hye-Shin Chung, Manjunatha B. Bhat, Sadashiva S. Karnik   +5 more
openalex   +1 more source

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, EarlyView.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Ligand-Induced Biased Activation of GPCRs: Recent Advances and New Directions from In Silico Approaches. [PDF]

Molecules
Hashem S, Dougha A, Tufféry P.
europepmc   +1 more source

BRET analysis of GPCR oligomerization: newer does not mean better

, 2006
Michel Bouvier, Nikolaus Heveker, Ralf Jockers, Stéfano Marullo, Graeme Milligan   +4 more
openalex   +2 more sources

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, EarlyView.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

GPCRVS - AI-driven Decision Support System for GPCR Virtual Screening. [PDF]

Int J Mol Sci
Latek D, Prajapati K, Dragan P, Merski M, Osial P.   +4 more
europepmc   +1 more source

AI‐Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorhabditis elegans

Aging Cell, EarlyView.
A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, Peter O. Fedichev   +5 more
wiley   +1 more source

High CX3CR1 expression predicts poor prognosis in paediatric acute myeloid leukaemia undergoing hyperleukocytosis

International Journal of Laboratory Hematology, Volume 45, Issue 1, Page 53-63, February 2023., 2023
Abstract Introduction Paediatric AML patients with hyperleukocytosis have a poor prognosis and higher early mortality. Therefore, more studies are needed to explore relevant prognostic indicators and develop effective prevention strategies for this type of childhood AML. Methods All original data were obtained from the TARGET database.
Nan Mei, Hong Su, Sha Gong, Hanzhi Du, Xiaojuan Zhang, Lu Wang, Huaiyu Wang   +6 more
wiley   +1 more source

The structural basis of the G protein-coupled receptor and ion channel axis. [PDF]

Curr Res Struct Biol
Luo Y, Sun L, Peng Y.
europepmc   +1 more source