Results 151 to 160 of about 61,419 (246)

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5887-5900, December 2022., 2022
Abstract Adenosine‐3′, 5′‐cyclic monophosphate (cAMP) produced by adenylate cyclases (ADCYs) is an established key regulator of cell homoeostasis. However, its role in cell cycle control is still controversially discussed. This study focussed on the impact of soluble HCO3− ‐activated ADCY10 on cell cycle progression.
Warunya Woranush, Mats Leif Moskopp, Thomas Noll, Peter Dieterich   +3 more
wiley   +1 more source

GPCR Sense Communication Among Interaction Nematodes with Other Organisms. [PDF]

Int J Mol Sci
Wang J, Guo C, Wei X, Pu X, Zhao Y, Xu C, Wang W.   +6 more
europepmc   +1 more source

Genome-wide pan-GPCR cell libraries accelerate drug discovery

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery.
Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen   +12 more
doaj  

Ligand-Binding Architecture of Human CB2 Cannabinoid Receptor: Evidence for Receptor Subtype-Specific Binding Motif and Modeling GPCR Activation [PDF]

, 2008
Ying Pei, Richard W. Mercier, Jenine K. Anday, Ganesh A. Thakur, A. M. Zvonok, Dow P. Hurst, Patricia H. Reggio, David R. Janero, Alexandros Makriyannis   +8 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Genetically encoded sensors illuminate <i>in vivo</i> detection for neurotransmission: Development, application, and optimization strategies. [PDF]

IBRO Neurosci Rep
Zhong X, Gu H, Lim J, Zhang P, Wang G, Zhang K, Li X.   +6 more
europepmc   +1 more source

Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format [PDF]

, 2008
Ke Liu, Steve Titus, Noel Southall, Pingjun Zhu, James Inglese, Christopher P. Austin, Wei Zheng   +6 more
openalex   +1 more source

Small fiber neuropathy with dysautonomia and positive GPCR and FGFR-3 antibodies after the first BNT162b2 dose. [PDF]

Clinics (Sao Paulo)
Finsterer J, Scorza CA, Scorza FA, Fiorini AC.   +3 more
europepmc   +1 more source