Results 161 to 170 of about 61,419 (246)

DEP-Domain-Mediated Regulation of GPCR Signaling Responses

, 2006
Daniel R. Ballon, Paul L. Flanary, Douglas P. Gladue, James B. Konopka, Henrik Dohlman, Jeremy Thorner   +5 more
openalex   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, EarlyView.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways. [PDF]

Nat Commun
Aranda-García D, Stepniewski TM, Torrens-Fontanals M, García-Recio A, Lopez-Balastegui M, Medel-Lacruz B, Morales-Pastor A, Peralta-García A, Dieguez-Eceolaza M, Sotillo-Nuñez D, Ding T, Drabek M, Jacquemard C, Jakowiecki J, Jespers W, Jiménez-Rosés M, Jun-Yu-Lim V, Nicoli A, Orzel U, Shahraki A, Tiemann JKS, Ledesma-Martin V, Nerín-Fonz F, Suárez-Dou S, Canal O, Pándy-Szekeres G, Mao J, Gloriam DE, Kellenberger E, Latek D, Guixà-González R, Gutiérrez-de-Terán H, Tikhonova IG, Hildebrand PW, Filizola M, Babu MM, Di Pizio A, Filipek S, Kolb P, Cordomi A, Giorgino T, Marti-Solano M, Selent J.   +42 more
europepmc   +1 more source

Faculty Opinions recommendation of Asymmetric conformational changes in a GPCR dimer controlled by G-proteins.

, 2006
Ralf Jockers
openalex   +1 more source

The Effect of Deletion of the Orphan G – Protein Coupled Receptor (GPCR) Gene MrgE on Pain-Like Behaviours in Mice [PDF]

, 2008
Peter J. Cox, Tom Pitcher, Steven A. Trim, Christine H Bell, Wenning Qin, Ross A. Kinloch   +5 more
openalex   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

An Alternative Mode of GPCR Transactivation: Activation of GPCRs by Adhesion GPCRs. [PDF]

Int J Mol Sci
Lin HH.
europepmc   +1 more source

1P478 Sequence and structure features of GPCRs, which are effective to determine the GPCR and G-protein binding selectivity(23. Bioinformatics, genomics and proteomics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Makiko Suwa, Takahiko Muramatsu
openalex   +2 more sources

The Predicted Binding Site and Dynamics of Peptide Inhibitors to the Methuselah GPCR from Drosophila melanogaster [PDF]

, 2008
Jiyoung Heo, William W. Ja, Seymour Benzer, William A. Goddard   +3 more
openalex   +1 more source

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, EarlyView.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source