Results 161 to 170 of about 92,178 (306)

Author Correction: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration

Scientific Reports
Chulo Park, Jin‑Woo Lee, Kiheon Kim, Dong‑Seung Seen, Jae‑Yeon Jeong, Won‑Ki Huh   +5 more
doaj   +1 more source

G Protein-Coupled Receptors in Cerebrovascular Diseases: Signaling Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Gu Q, Yao J, Sheng J, Liu D.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Dense and distributed neuropeptide network in the nerve net of Hydra vulgaris. [PDF]

PLoS Comput Biol
De La Cruz Rothenfusser J, Yáñez-Guerra LA, Teufel F, Yuste R.   +3 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex. [PDF]

Sci Adv
Dagunts A, Adoff H, Novy B, Ameur LB, De Maria M, Saunders A, Lobingier BT.   +6 more
europepmc   +1 more source

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Journal of gastroenterology, 2016
Mingming Sun, Wei Wu, Zhanju Liu, Y. Cong   +3 more
semanticscholar   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

A progressive fine-tuning framework with dynamic parameter selection for low-resource peptide-GPCR interaction prediction. [PDF]

Brief Bioinform
Liu M, Xu J, Liu J.
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source