Results 171 to 180 of about 61,419 (246)

AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist. [PDF]

J Cheminform
Brahma R, Moon S, Shin JM, Cho KH.
europepmc   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor [PDF]

, 2008
Jo Ann Janovick, Akshay Patny, Ralph Mosley, Mark T. Goulet, Michael D. Altman, Thomas S. Rush, Anda Cornea, P. Michael Conn   +7 more
openalex   +1 more source

Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Whereas biased agonism on the 5‐HT2A receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In schizophrenia, increased 5‐HT2A receptor constitutive activity has been suggested, highlighting the therapeutic relevance of inverse ...
Itziar Muneta‐Arrate, Patricia Miranda‐Azpiazu, Igor Horrillo, Rebeca Diez‐Alarcia, J. Javier Meana   +4 more
wiley   +1 more source

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective. [PDF]

Innovation (Camb)
Bi Z, Li H, Liang Y, Sun D, Liu S, Chen W, Leng L, Song C, Zhang S, Cong Z, Chen S.   +10 more
europepmc   +1 more source

Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs

British Journal of Pharmacology, EarlyView.
Graph‐based algorithms that enable efficient computations of all H‐bonds present in structures in entire datasets allow us to dissect H‐bond fingerprints that characterize distinct GPCRs and the structures sampled along their activation. Abstract Changes in structure and dynamics elicited by agonist ligand binding at the extracellular side of G protein
Éva Bertalan, Matthew Joseph Rodrigues, Gebhard F. X. Schertler, Ana‐Nicoleta Bondar   +3 more
wiley   +1 more source

Jaw1 accelerates the reaction speed of the Ca²⁺ signals via ITPRs upon GPCR stimulation. [PDF]

Sci Rep
Kozono T, Matsui H, Bandalan MF, Tonozuka T, Nishikawa A.   +4 more
europepmc   +1 more source

The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]

, 2008
Karl Nordström, Malin C. Lagerström, L. M. J. Waller, Robert Fredriksson, Helgi B. Schiöth   +4 more
openalex   +1 more source

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

British Journal of Pharmacology, EarlyView.
Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link, Jakob Sture Madsen, David E. Gloriam, Hans Bräuner‐Osborne, Alexander S. Hauser   +4 more
wiley   +1 more source

Lineage-Specific Class-A GPCR Dynamics Reflect Diverse Chemosensory Adaptations in Lophotrochozoa. [PDF]

Mol Biol Evol
Nath R, Panda B, Rakesh S, Krishnan A.
europepmc   +1 more source