Results 171 to 180 of about 92,511 (354)
In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies [PDF]
, 2022 Sebastian Fritzwanker +3 more
openalex +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Faculty Opinions recommendation of Biased agonism: An emerging paradigm in GPCR drug discovery.
, 2017 Marcin Chwistek
openalex +2 more sources
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
G protein-coupled receptor digital twins for precision and personalized medicine. [PDF]
Comput Struct Biotechnol JBoeringer T +3 more
europepmc +1 more source
Structural elucidation of ligand binding sites in family B GPCRs and their application in drug discovery [PDF]
, 2016 Ali Jazayeri +14 more
openalex +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source