Results 181 to 190 of about 61,419 (246)

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Artificial Intelligence: A New Tool for Structure-Based G Protein-Coupled Receptor Drug Discovery. [PDF]

Biomolecules
Chung J, Hahn H, Flores-Espinoza E, Thomsen ARB.   +3 more
europepmc   +1 more source

Double GPCR trouble [PDF]

, 2008
Charlotte Harrison
openalex   +1 more source

Altered desensitization and internalization patterns of rodent versus human glucose‐dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The gut hormone glucose‐dependent insulinotropic polypeptide (GIP) signals via the GIP receptor (GIPR), resulting in postprandial potentiation of glucose‐stimulated insulin secretion. The translation of results from rodent studies to human studies has been challenged by the unexpected effects of GIPR‐targeting compounds.
Lærke Smidt Gasbjerg, Rasmus Syberg Rasmussen, Adrian Dragan, Peter Lindquist, Josefine Ulrikke Melchiorsen, Tomasz Maciej Stepniewski, Sine Schiellerup, Esther Karen Tordrup, Sarina Gadgaard, Hüsün Sheyma Kizilkaya, Sabine Willems, Yi Zhong, Yi Wang, Shane C. Wright, Volker M. Lauschke, Bolette Hartmann, Jens Juul Holst, Jana Selent, Mette Marie Rosenkilde   +18 more
wiley   +1 more source

GPCR dimerization: Drug discovery aspects and targets in renin-angiotensin systems. [PDF]

FASEB Bioadv
Faisal T, Hussain T.
europepmc   +1 more source

GPCR Engineering Yields High-Resolution Structural Insights into β ₂ -Adrenergic Receptor Function

, 2007
Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson, Søren G. F. Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee‐Jung Choi, Xiao-Jie Yao, William I. Weis, Raymond C. Stevens, Brian K. Kobilka   +10 more
openalex   +1 more source

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, EarlyView.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism. [PDF]

Front Mol Neurosci
Qiu T, Fu O.
europepmc   +1 more source

Evaluation of Cellular Dielectric Spectroscopy, a Whole-Cell, Label-Free Technology for Drug Discovery on Gi-Coupled GPCRs

, 2007
Matthew F. Peters, Katharine S. Knappenberger, Deidre Wilkins, Linda A. Sygowski, Lois Ann Lazor, Jianwei Liu, Clay W. Scott   +6 more
openalex   +1 more source

Allosterism in the adenosine A2A and cannabinoid CB2 heteromer

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent, Iu Raïch, Angel Gonzalez, Jaume Lillo, Nil Casajuana‐Martin, Rafael Franco, Leonardo Pardo, Gemma Navarro   +7 more
wiley   +1 more source