Results 181 to 190 of about 142,523 (351)

ligand Recognition and Structural Change of GPCR

, 2001
Masaji Ishiguro
openalex   +2 more sources

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Primary structure and expression patterns of Ci-RGR1, a novel GPCR of the ascidian Ciona intestinalis

, 2001
Yuki Nakashima, Ryoko Kusakabe, Takehiro Kusakabe, M. Tuda   +3 more
openalex   +2 more sources

Bridging the GPCR gap [PDF]

, 2006
Joanna Owens
openalex   +1 more source

Structure and dynamics of GPCR signaling complexes

Nature Structural & Molecular Biology, 2017
D. Hilger, M. Masureel, B. Kobilka
semanticscholar   +1 more source

SNX9 family mediates βarrestin-independent GPCR endocytosis

Communications Biology
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Valeria L. Robleto, Ya Zhuo, Joseph M. Crecelius, Sara Benzow, Adriano Marchese   +4 more
doaj   +1 more source

Miniaturization of Whole Live Cell-Based GPCR Assays Using Microdispensing and Detection Systems

, 2004
Oleg Kornienko, Raul Lacson, Priya Kunapuli, Jonathan E. Schneeweis, Ira Hoffman, Todd Smith, Melissa Alberts, James Inglese, Berta Strulovici   +8 more
openalex   +1 more source

Statistical analysis and prediction of functional residues effective for GPCR-G-protein coupling selectivity [PDF]

, 2006
Toshiya Muramatsu, Makiko Suwa
openalex   +1 more source

Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues

Lipids, EarlyView.
ABSTRACT Omega‐3 and omega‐6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega‐3 and reducing omega‐6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced ...
Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak‐Hong, Katherine Ness Shipley, Nicholas M. Salem, Ann I. Scher, Matthew R. Sapio, Michael J. Iadarola, Christopher E. Ramsden   +8 more
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source