Results 181 to 190 of about 113,722 (335)
ABSTRACT Objective To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin. Design Prospective ex vivo laboratory study. Setting Mount Sinai Hospital, Toronto. Population Full‐term parturients who underwent elective caesarean deliveries (CD).
Mrinalini Balki+5 more
wiley +1 more source
Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli+7 more
wiley +1 more source
A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov+5 more
wiley +1 more source
Proteomic applications of automated GPCR classification [PDF]
Matthew N. Davies+6 more
openalex +1 more source
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan+15 more
wiley +1 more source
Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor [PDF]
Jennifer Alexander‐Brett+1 more
openalex +1 more source
The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis. [PDF]
Heinen M, Rovenich H, Altegoer F.
europepmc +1 more source
Luteinizing hormone receptor knockout mouse: What has it taught us?
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley +1 more source
The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery
G protein-coupled receptors (GPCRs) are crucial players in various physiological processes, making them attractive candidates for drug discovery. However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.
Wei Chen+4 more
doaj