Results 211 to 220 of about 92,511 (354)

State-Specific Peptide Design Targeting G Protein-Coupled Receptors. [PDF]

J Chem Inf Model
Xue Y, Wang H, Li J, Hu J, Chen Z, Zheng Z, Liu L, Zhu K, He J, Gong H, Li X, Zhang X, Fang X.   +12 more
europepmc   +1 more source

Loss-of-function Gα _s rare disease variants exert mutation-specific effects on GPCR signaling

Theo Redfern-Nichols, Shannon O’Brien, Xianglin Huang, Brian Medel-Lacruz, Davide Calebiro, Jana Selent, Graham Ladds, Maria Martí-Solano   +7 more
openalex   +2 more sources

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization. [PDF]

NPJ Vaccines
Liu ES, Ho KW, Wu CC, Fan HL, Wang TY, Hsieh YC, Huang BC, Hong ST, Liao TY, Liu YL, Chen YT, Lee CC, Chen CY, Lin CL, Cheng TL.   +14 more
europepmc   +1 more source

FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans [PDF]

Kavita Babu, Umer Saleem Bhat, Siju Surendran, H Sharanya, Jun Liu, Yang Xu, Namra Tasnim, Muhammad Nadeem Abbas, Ashwani Bhardwaj, Monika Scholz   +9 more
openalex   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, EarlyView.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Class A GPCR: Di/Oligomerization of Glycoprotein Hormone Receptors

, 2017
Aylin C. Hanyaloglu, Francesca Fanelli, Kim Jonas   +2 more
openalex   +2 more sources

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling [PDF]

, 2017
Mayu Kasubuchi, Keita Watanabe, Kanako Hirano, Daisuke Inoue, Xuan Li, Kazuya Terasawa, Morichika Konishi, Nobuyuki Itoh, Ikuo Kimura   +8 more
openalex   +1 more source

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Nature reviews. Drug discovery, 2018
I. Shimada, Takumi Ueda, Yutaka Kofuku, M. Eddy, K. Wüthrich   +4 more
semanticscholar   +1 more source

Novel <i>GNAO1</i> variant in α-helical domain reveals alternative mechanism of disease. [PDF]

Genes Dis
Ludlam WG, Domínguez-Carral J, Schteinschnaider A, Martemyanov KA, Ortigoza-Escobar JD.   +4 more
europepmc   +1 more source