Results 211 to 220 of about 119,228 (259)
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Life Sciences, 2003
The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
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The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
openaire +2 more sources
2007
Many GPCR models have been built over the years for many different purposes, of which drug-design undoubtedly has been the most frequent one. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today.
Paiva, A.C. +4 more
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Many GPCR models have been built over the years for many different purposes, of which drug-design undoubtedly has been the most frequent one. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today.
Paiva, A.C. +4 more
openaire +3 more sources
Journal of the American Chemical Society, 2005
This paper describes G-protein-coupled receptor (GPCR) microarrays on porous glass substrates and functional assays based on the binding of a europium-labeled GTP analogue. The porous glass slides were made by casting a glass frit on impermeable glass slides and then coating with gamma-aminopropyl silane (GAPS). The emitted fluorescence was captured on
Yulong, Hong +18 more
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This paper describes G-protein-coupled receptor (GPCR) microarrays on porous glass substrates and functional assays based on the binding of a europium-labeled GTP analogue. The porous glass slides were made by casting a glass frit on impermeable glass slides and then coating with gamma-aminopropyl silane (GAPS). The emitted fluorescence was captured on
Yulong, Hong +18 more
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GPCR-Interacting Proteins, Major Players of GPCR Function
2011G protein-coupled receptors (GPCRs) are, with approximately 800 members, among the most abundant membrane proteins in humans. They are responding to a plethora of ligands and are involved in the transmission of extracellular signals inside the cell. GPCRs are synthesized in the endoplasmatic reticulum and are then transported to the cell surface where ...
Maurice, Pascal +5 more
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Production of GPCR and GPCR complexes for structure determination
Current Opinion in Structural Biology, 2013Since the first high-resolution structure of the beta 2 adrenergic receptor (b2AR) in 2007, we have seen a growing number of G-protein-coupled receptor (GPCR) structures coming to the repertory, providing a significant progress in our understanding of the structural basis of their function.
Maeda Shoji, Schertler Gebhard FX X
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Nature Chemical Biology, 2019
An in silico directed evolution approach using first principles of allostery predicts the effects of protein sequence and structure variation on constitutive activity and ligand response in GPCRs.
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An in silico directed evolution approach using first principles of allostery predicts the effects of protein sequence and structure variation on constitutive activity and ligand response in GPCRs.
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2021
Senior Students at Taft High School: Karen Butler, 17 yrs.; Naomi Grimes, 18 yrs.; Jackie Glover, 18 yrs.
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Senior Students at Taft High School: Karen Butler, 17 yrs.; Naomi Grimes, 18 yrs.; Jackie Glover, 18 yrs.
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