Results 211 to 220 of about 113,722 (335)

Modulating the Properties of GPCR-Based Sensors Via C-Terminus Isoforms. [PDF]

ACS Synth Biol
Marquez-Gomez PL, Damiano SR, Torp LR, Peralta-Yahya P.   +3 more
europepmc   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

A GLP‐1R/Y1 receptor/Y2 receptor triple agonist decreases fentanyl‐evoked dopamine release in the nucleus accumbens and attenuates fentanyl taking and seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey, Enzo Lavecchia, Kylie S. Chichura, Matthew R. Hayes, Robert P. Doyle, Heath D. Schmidt   +5 more
wiley   +1 more source

Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease. [PDF]

Int J Mol Sci
Buqaileh R, Alshriem LA, AbouAlaiwi W.
europepmc   +1 more source

Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction. [PDF]

Biomolecules
Ridgway H, Moore GJ, Gadanec LK, Matsoukas JM.   +3 more
europepmc   +1 more source

Opioid receptors in cardiovascular function

British Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari, Kesha K. Dalal, Narendra Kondapalli, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

Ligand-Binding Architecture of Human CB2 Cannabinoid Receptor: Evidence for Receptor Subtype-Specific Binding Motif and Modeling GPCR Activation [PDF]

, 2008
Ying Pei, Richard W. Mercier, Jenine K. Anday, Ganesh A. Thakur, A. M. Zvonok, Dow P. Hurst, Patricia H. Reggio, David R. Janero, Alexandros Makriyannis   +8 more
openalex   +1 more source

Loss-of-function Gα_s rare disease variants exert mutation-specific effects on GPCR signaling. [PDF]

Sci Signal
Redfern-Nichols T, O'Brien SL, Huang X, Medel-Lacruz B, Calebiro D, Selent J, Ladds G, Marti-Solano M.   +7 more
europepmc   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Faculty Opinions recommendation of Asymmetric conformational changes in a GPCR dimer controlled by G-proteins.

, 2006
Ralf Jockers
openalex   +1 more source