Results 211 to 220 of about 142,523 (351)

Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations

ChemistryOpen, EarlyView.
A systematic computational workflow integrates Protein–Ligand Affinity prediction NETwork (PLANET), a GPU‐accelerated version of AutoDock Vina (Vina‐GPU), molecular mechanics/generalized born surface area (MM/GBSA), absorption distribution metabolism excretion toxicity prediction (admetSAR 3.0), molecular dynamics (MD), and absolute binding free energy
Xi Chen, Xinle Yang, Roufen Chen, Lei Xu, Xiaowu Dong, Zhen Cai   +5 more
wiley   +1 more source

Manifold active‐state conformations in GPCRs: Agonist‐activated constitutively active mutant AT₁ receptor preferentially couples to Gq compared to the wild‐type AT₁ receptor [PDF]

, 2007
ChangWoo Lee, Si Ae Hwang, Sei-Heon Jang, Hye-Shin Chung, Manjunatha B. Bhat, Sadashiva S. Karnik   +5 more
openalex   +1 more source

Expanding the Reach of Membrane Protein–Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

PROTEOMICS, EarlyView.
ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos, Ashim Bhattacharya, Mohammed Al‐Seragi, Franck Duong van Hoa   +3 more
wiley   +1 more source

Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk. [PDF]

Cardiovasc Res
Camargo Tavares L, R Muralitharan R, Snelson M, Marques FZ.   +3 more
europepmc   +1 more source

DEP-Domain-Mediated Regulation of GPCR Signaling Responses

, 2006
Daniel R. Ballon, Paul L. Flanary, Douglas P. Gladue, James B. Konopka, Henrik Dohlman, Jeremy Thorner   +5 more
openalex   +1 more source

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

Pest Management Science, EarlyView.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa, Kimberly H. Lohmeyer, Patricia V. Pietrantonio   +2 more
wiley   +1 more source

Letter to editor: SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. [PDF]

J Transl Med
Zhang X, Cong Y, Zheng X, Wu G.
europepmc   +1 more source

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor [PDF]

, 2008
Jo Ann Janovick, Akshay Patny, Ralph Mosley, Mark T. Goulet, Michael D. Altman, Thomas S. Rush, Anda Cornea, P. Michael Conn   +7 more
openalex   +1 more source

Unraveling the Metabolic Influence of Olfactory Receptors in Cancer Cells

Sensory Neuroscience, EarlyView.
ORs are aberrantly expressed in various tumor types and regulate cancer cell metabolism through nonclassical signaling pathways, including PI3K/Akt, MAPK, and ERK. These receptors influence tumor proliferation, invasion, and immune evasion. Specific OR–ligand interactions offer promising opportunities for targeted cancer therapy and early diagnosis ...
Chengzhilin Li, Xiaochen Gao, Ziheng Liu, Nianlei Zhang, Xue Cao, Wenwen Qi, Chengcheng Liu   +6 more
wiley   +1 more source

Functional Autoantibodies Targeting G-Protein-Coupled Receptors and Their Clinical Phenotype in Patients with Long-COVID. [PDF]

Int J Mol Sci
Hofmann S, Lucio M, Wallukat G, Hoffmanns J, Schröder T, Raith F, Szewczykowski C, Skornia A, Rech J, Schottenhamml J, Harrer T, Ganslmayer M, Mardin C, Flecks M, Lakatos P, Hohberger B.   +15 more
europepmc   +1 more source