Results 241 to 250 of about 142,523 (351)

Assembly of a GPCR-G Protein Complex

Cell, 2019
Yang Du, N. M. Duc, S. Rasmussen, D. Hilger, X. Kubiak, Liwen Wang, J. Bohon, H. Kim, M. Wegrecki, Awuri P Asuru, K. Jeong, Jeongmi Lee, M. Chance, D. Lodowski, B. Kobilka, K. Chung   +15 more
semanticscholar   +1 more source

USP44, ZNF454, and GPRC5B ctDNA Methylation Markers in Breast Cancer: Limited Clinical Relevance for Disease Monitoring and Tumor Characteristics

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We selected breast cancer‐specific DNA methylation markers using The Cancer Genome Atlas (TCGA). We analyzed the methylation and expression patterns of candidate genes in breast cancer cell lines, ctDNA, and tissue samples. The relationship between ctDNA methylation markers and the clinicopathological features of breast cancer patients was investigated.
Young Ju Jeong, Chang‐Ho Jeon, Hoon Kyu Oh, Jeong Kyu Kim, Chun‐Seok Yang, Na‐Rang Lee, Doyeon Kim   +6 more
wiley   +1 more source

The function of GPCRs in different bone cells. [PDF]

Int J Biol Sci
Zhang Y, Wang NN, Qiu ZH, Wang JH, An WN, Shi LD, Chen F, Zhang DJ, Wang SY, Yang TL, Hu SY, Guo Y.   +11 more
europepmc   +1 more source

Myeloid cAMP Reduction Shifts Rhinovirus‐Induced Airway Inflammation From Neutrophilic to Eosinophilic by Suppressing M1‐Interstitial Macrophages

Allergy, EarlyView.
ABSTRACT Background Asthma exacerbations caused by human rhinovirus (hRV) infection are characterized by airway neutrophilia and reduced corticosteroid response, leading to significant healthcare costs and lung function impairment. The Gαs subunit of the trimeric G protein regulates immunopathological conditions by modulating cAMP levels.
Seong Ok Park, Erdenebileg Uyangaa, Hyo Jin Kim, Hee Won Byeon, Jin Young Choi, Koanhoi Kim, Jihyung Lee, Samuel Bertin, Eyal Raz, Seong Kug Eo   +9 more
wiley   +1 more source

Pain management beyond opioids: a β-arrestin2-biased allosteric GPCR modulator opens new avenues for drug development. [PDF]

Signal Transduct Target Ther
Pottie E, Steinmüller SAM, Decker M.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation. [PDF]

Nat Commun
Matthees ESF, Haider RS, Klement L, Reichel M, Blum NK, Weitzel V, Trüpschuch T, Ziegler C, Drube J, Schulz S, Hoffmann C.   +10 more
europepmc   +1 more source

GPCR Engineering Yields High-Resolution Structural Insights into β ₂ -Adrenergic Receptor Function

, 2007
Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson, Søren G. F. Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee‐Jung Choi, Xiao-Jie Yao, William I. Weis, Raymond C. Stevens, Brian K. Kobilka   +10 more
openalex   +1 more source

The Predicted Binding Site and Dynamics of Peptide Inhibitors to the Methuselah GPCR from Drosophila melanogaster [PDF]

, 2008
Jiyoung Heo, William W. Ja, Seymour Benzer, William A. Goddard   +3 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source