Results 261 to 270 of about 113,722 (335)

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +1 more source

To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract. [PDF]

World J Gastroenterol
Cui ZJ.
europepmc   +1 more source

Sex‐dimorphic gene regulation in murine macrophages across niches

Immunology &Cell Biology, EarlyView.
In this study, we perform a meta‐analysis of new and publicly available RNA‐seq datasets from male and female mouse macrophages across eight niches to identify conserved sex‐dimorphic gene expression patterns. We found that three sex chromosome‐linked genes are always differentially expressed between males and females: Ddx3y, Eif2s3y and Xist. However,
Cassandra J McGill, Olivia S White, Ryan J Lu, Nirmal K Sampathkumar, Bérénice A Benayoun   +4 more
wiley   +1 more source

Ligand-Induced Biased Activation of GPCRs: Recent Advances and New Directions from In Silico Approaches. [PDF]

Molecules
Hashem S, Dougha A, Tufféry P.
europepmc   +1 more source

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Developing muscarinic receptor M1 classification models utilizing transfer learning and generative AI techniques. [PDF]

Sci Rep
Dey S, Wallqvist A, AbdulHameed MDM.
europepmc   +1 more source

Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF‐α Levels in Target Organs, and Protects Mice From Graft‐Versus‐Host Disease‐Related Mortality Through PPAR Activation Without Compromising the Graft‐Versus‐Tumour Response

Immunology, EarlyView.
Effect of Palmitoylethanolamide (PEA) in a murine model of graft‐versus‐host disease (GVHD). Following an allogeneic transplant from C57BL/6J donors to BALB/c recipients, PEA treatment improved survival, alleviated clinical symptoms, and protected target organs in GVHD‐affected mice.
Bárbara Betônico Berg, Zara Desiree Tonidandel Campos, Gioconda Muniz Fiorenza Ruggio, Ana Flávia Santos Linhares, Bárbara Maximino Rezende, Stêfany Bruno de Assis Cau, Thiago Roberto Lima Romero, Mauro Martins Teixeira, Vanessa Pinho, Marina Gomes Miranda Castor   +9 more
wiley   +1 more source

GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner. [PDF]

Commun Biol
Löbbert A, Lorz N, Matthees ESF, Rößler P, Hoffmann C, Gossert AD.   +5 more
europepmc   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Multiplexed Assays by High-Content Imaging for Assessment of GPCR Activity

, 2008
D. A. Ross, S. Lee, Vladimı́r Reiser, Junli Xue, K. Alves, Sravanti Vaidya, Anthony Kreamer, Rebecca Mull, Ed Hudak, Terri Hare, P A Detmers, R. B. Lingham, Marc Ferrer, Berta Strulovici, Francesca Santini   +14 more
openalex   +1 more source