Results 261 to 270 of about 92,511 (354)

Subcellular Organization of GPCR Signaling.

TIPS - Trends in Pharmacological Sciences, 2018
Kelsie Eichel, M. von Zastrow
semanticscholar   +1 more source

RePol: A high‐throughput screen for optimizing membrane protein solubilization and purification using polymers

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Extraction and purification of membrane proteins has for a long time represented a significant challenge. Polymer‐based extraction methods, like those using styrene maleic acid co‐polymers have provided a fertile approach to generate samples that include the local lipid environment surrounding the protein.
Adam Evans, Bethan Kelly, Pooja Sridhar, Alice J. Rothnie, Naomi L. Pollock, Philip M. Ireland, David I. Roper, Tim R. Dafforn   +7 more
wiley   +1 more source

Activity‐restoring mutations in the histamine H3 receptor increase constitutive activity and reduce structural stability

Protein Science, Volume 35, Issue 1, January 2026.
Abstract The histamine H3 receptor (H3R) is a class A G protein‐coupled receptor (GPCR) that regulates neurotransmitter release in the central nervous system. Although structures of H3R in both inactive and active states have been elucidated, the functional roles of specific residues remain unclear.
Ami Nakajima, Hiroto Kaneko, Kosuke Oyama, Misumi Kuchiji, Ayane Itakura, Chiaki Arai, Mitsunori Shiroishi   +6 more
wiley   +1 more source

Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk. [PDF]

Cardiovasc Res
Camargo Tavares L, R Muralitharan R, Snelson M, Marques FZ.   +3 more
europepmc   +1 more source

Phosphorylation induces altered protonation states and allosterically regulates Rac1–RhoGDI complex

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Krishnendu Sinha, Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty   +4 more
wiley   +1 more source

Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity. [PDF]

J Biol Chem
Sun X, Brueck L, Yang D, Sheets PL, Zhou B, Ren H.   +5 more
europepmc   +1 more source

Using Ligand‐Based Virtual Screening to Allosterically Stabilize the Activated State of a GPCR

, 2010
Christina Taylor, Nicole B. Rockweiler, Cassie Liu, Loryn Rikimaru, Anna‐Karin Tunemalm, Oleg G. Kisselev, Garland R. Marshall   +6 more
openalex   +2 more sources

State‐dependent regulation of the Kv7.2 channel voltage sensor by QO‐58

British Journal of Pharmacology, Volume 183, Issue 2, Page 333-348, January 2026.
Background and Purpose KV7(KCNQ) potassium channels are key modulators of neuronal excitability, and promising targets for development of drugs for epilepsy and pain. We investigated a candidate KV7 drug, QO‐58, which has been previously described but has an unclear mechanism of action.
Richard Kanyo, Shawn M. Lamothe, Thomas M. Hammond, Harley T. Kurata   +3 more
wiley   +1 more source

Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
Eli C. Olson, Adam Williams, Stephanie C. Eisenbarth   +2 more
wiley   +1 more source

Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria. [PDF]

Genetics
Schwarz EM, Baniya A, Heppert JK, Schwartz HT, Tan CH, Antoshechkin I, Sternberg PW, Goodrich-Blair H, Dillman AR.   +8 more
europepmc   +1 more source