Results 271 to 280 of about 142,523 (351)

The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis. [PDF]

PLoS Pathog
Heinen M, Rovenich H, Altegoer F.
europepmc   +1 more source

Subcellular Organization of GPCR Signaling.

TIPS - Trends in Pharmacological Sciences, 2018
Kelsie Eichel, M. von Zastrow
semanticscholar   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM. [PDF]

Sci Rep
Castel J, Botzanowski T, Brooks I, Frechard A, Bey G, Schroeter M, Del Nero E, Debaene F, Ciesielski F, Zeyer D, Cianferani S, Morales R.   +11 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Functional characterization of lactate metabolism and its key regulatory genes reveals lactate-mediated modulation of carbon and nitrogen metabolism in Phaeodactylum tricornutum. [PDF]

Microb Cell Fact
Duan J, Zhang Y, Li C, Zheng Y, Zeng Y, Zhang X, Cai X, Long H, Ren W, Xie Z, Huang A.   +10 more
europepmc   +1 more source

State‐dependent regulation of the Kv7.2 channel voltage sensor by QO‐58

British Journal of Pharmacology, EarlyView.
Background and Purpose KV7(KCNQ) potassium channels are key modulators of neuronal excitability, and promising targets for development of drugs for epilepsy and pain. We investigated a candidate KV7 drug, QO‐58, which has been previously described but has an unclear mechanism of action.
Richard Kanyo, Shawn M. Lamothe, Thomas M. Hammond, Harley T. Kurata   +3 more
wiley   +1 more source

Evaluation of Small-Molecule Binding Site Prediction Methods on Membrane-Embedded Protein Interfaces. [PDF]

J Chem Inf Model
Pliushcheuskaya P, Künze G.
europepmc   +1 more source

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

, 2008
Hongfei Ge, Jennifer Weiszmann, Jeff D. Reagan, Jamila Gupte, Hélène Baribault, Tibor Gyuris, Jinlong Chen, Hui Tian, Yang Li   +8 more
openalex   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source