Results 271 to 280 of about 92,511 (354)

Atypical p38 Kinase Signaling in Retinal Vascular Damage and Recovery

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Using an oxygen‐induced retinopathy model, we demonstrate that Tab1‐dependent atypical p38 activation contributes to retinal vascular injury. Genetic blockade of this pathway protects against pathological neovascularization by modulating transcriptional programs.
Lillian Schulz, Abby E. Young, Fang Liu, Sanjana Gattineni, Sneha S. Ghosh, Eugene Douglass, Heike Kroeger, S. Priya Narayanan, Neil J. Grimsey   +8 more
wiley   +1 more source

Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids. [PDF]

J Biol Chem
Edin ML, Graves JP, Zeldin DC.
europepmc   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, Volume 20, Issue 24, December 15, 2025.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Letter to editor: SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. [PDF]

J Transl Med
Zhang X, Cong Y, Zheng X, Wu G.
europepmc   +1 more source

Dual Targeting Approach Using 4‐Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue

ChemMedChem, Volume 20, Issue 24, December 15, 2025.
The [F7,P34]‐pNPY based peptide‐drug conjugate targets the Y1 receptor and induces internalization. Once inside the cell, 4‐hydroxytamoxifen is cleaved from the peptide and is released into the cytosol, where it activates the estrogen receptor α. This dual‐targeting mechanism aims to promote body weight loss and offers a potential therapeutic strategy ...
Anna Kohler, Eva‐Maria Jülke, Luke C. Darveniza, Jan Stichel, Annette G. Beck‐Sickinger   +4 more
wiley   +1 more source

Probing spatiotemporally organized GPCR signaling using genetically encoded molecular tools. [PDF]

Exp Mol Med
Kwon Y, Mehta S, Zhang J.
europepmc   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]

Sci Signal
Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM.   +8 more
europepmc   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, Volume 15, Issue 12, Page 1955-1962, December 2025.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

CRISPR screen identifies CNIH1 as a selective driver of GPCR export

Assoumou K, Drugachenok P, Arrate IM, Zhang X, Braun SMG, Stoeber M.   +5 more
europepmc   +1 more source