Results 281 to 290 of about 113,722 (335)

Risk of Second Primary Neoplasms Among Cancer Survivors: A Population-Based, Cohort Study in Golestan Province, Northern Iran, 2004-2019. [PDF]

Cancer Med
Hasanpour-Heidari S, Semnani S, Fazel A, Naeimi-Tabiei M, Mehrjerdian M, Sedaghat S, Sadeghzadeh H, Salamat F, Jafari-Delouei N, Ghasemi-Kebria F, Mirkarimi H, Shokouhifar N, Abedi-Ardekani B, Weiderpass E, Roshandel G, Malekzadeh R.   +15 more
europepmc   +1 more source

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Single‐cell transcriptomics of human organoid‐derived enteroendocrine cell populations from the small intestine

The Journal of Physiology, EarlyView.
Abstract figure legend Human intestinal organoids were genetically modified to express a fluorescent protein in enteroendocrine cells (EECs), which were then separated by flow cytometry and analysed by single‐cell RNA sequencing. High numbers of human EECs were thereby available for cluster analysis and differential gene expression, revealing ...
Christopher A. Smith, Van B. Lu, Rula Bany Bakar, Emily Miedzybrodzka, Adam Davison, Deborah Goldspink, Frank Reimann, Fiona M. Gribble   +7 more
wiley   +1 more source

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

, 2009
Thomas E. Angel, Sayan Gupta, Beata Jastrzȩbska, Krzysztof Palczewski, Mark R. Chance   +4 more
openalex   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

Genetically encoded sensors illuminate <i>in vivo</i> detection for neurotransmission: Development, application, and optimization strategies. [PDF]

IBRO Neurosci Rep
Zhong X, Gu H, Lim J, Zhang P, Wang G, Zhang K, Li X.   +6 more
europepmc   +1 more source

Signaling by GPCR

Reactome - a curated knowledgebase of biological pathways, 2008
openaire   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Small fiber neuropathy with dysautonomia and positive GPCR and FGFR-3 antibodies after the first BNT162b2 dose. [PDF]

Clinics (Sao Paulo)
Finsterer J, Scorza CA, Scorza FA, Fiorini AC.   +3 more
europepmc   +1 more source