Results 281 to 290 of about 142,523 (351)

When G Protein-Coupled Receptor Signaling Meets the Primary Cilium: Implications for Sonic Hedgehog Signaling. [PDF]

Bioessays
Kim SE.
europepmc   +1 more source

Selectivity determinants of GPCR–G-protein binding

Nature, 2017
T. Flock, A. Hauser, N. Lund, David E. Gloriam, S. Balaji, M. M. Babu   +5 more
semanticscholar   +1 more source

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, EarlyView.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source

Insights into the structural dynamics of the secretin family (class B1) G protein-coupled receptors. [PDF]

J Biol Chem
Liu T, Naidoo NR, Agyemang E, Lamichhane R.   +3 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants

Jamaluddin A, Wyatt RA, Broichhagen J, Levitz J, Gorvin CM.   +4 more
europepmc   +1 more source

Multiplexed Assays by High-Content Imaging for Assessment of GPCR Activity

, 2008
D. A. Ross, S. Lee, Vladimı́r Reiser, Junli Xue, K. Alves, Sravanti Vaidya, Anthony Kreamer, Rebecca Mull, Ed Hudak, Terri Hare, P A Detmers, R. B. Lingham, Marc Ferrer, Berta Strulovici, Francesca Santini   +14 more
openalex   +1 more source

Tumor‐Derived Prostaglandin E2 Promotes Colorectal Cancer Progression by Inducing N2‐Type TAN Polarization

Cancer Science, EarlyView.
We demonstrated that PGE2 released from LDs in CRC cells plays important roles in N2‐type TANs polarization. PGE2 enters neutrophils through its receptor EP2/EP4 to stimulate ROS‐mediated FOXO3a methylation, thereby increasing the polarization of N2‐type TANs.
Yue Han, Wen Chen, Bin Zhang, Shuang Wang   +3 more
wiley   +1 more source

Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum. [PDF]

Parasit Vectors
Wang X, Fang C, Cheng G.
europepmc   +1 more source

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

, 2008
Justin T. Brown, Andrew Kant, Richard B. Mailman   +2 more
openalex   +2 more sources