Results 301 to 310 of about 142,523 (351)

Intracellular GPCR modulators enable precision pharmacology. [PDF]

NPJ Drug Discov
Krumm BE, Roth BL.
europepmc   +1 more source

Neuronal oscillatory imbalances in GNAO1‐related disorders associated with disease severity

Epilepsia, EarlyView.
Abstract Objective This study investigates excitatory/inhibitory (E/I) imbalances in GNAO1‐related disorders (GNAO1‐RD), linking neuronal dysfunction to clinical severity using E/I‐sensitive electroencephalography (EEG) analyses. Methods We conducted an observational study involving 12 children with GNAO1‐RD caused by pathogenic variants and 36 age ...
Tongyu Wang, Jana Domínguez‐Carral, William Grant Ludlam, Mar Junyent Segarra, Montserrat Fornaguera Marti, Hilgo Bruining, Kirill A. Martemyanov, Klaus Linkenkaer‐Hansen, Juan Dario Ortigoza‐Escobar   +8 more
wiley   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, EarlyView.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source

Effects of Membrane Cholesterol on the Structure and Function of Selected Class A GPCRs─Challenges and Future Perspectives. [PDF]

Biochemistry
Christofidi M, Tzortzini E, Mavromoustakos T, Kolocouris A.   +3 more
europepmc   +1 more source

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages

The FEBS Journal, EarlyView.
Butyrate mitigates intestinal inflammation in IBD. It does so primarily by suppressing pro‐inflammatory cytokines and costimulatory molecules in activated monocytes and macrophages, concomitant with enhancing pathogen clearance. In human colonic organoids, butyrate promotes epithelial expression of key genes involved in barrier function and immune ...
Daniela Parada‐Venegas, Marjorie De la Fuente López, Karen Dubois‐Camacho, Glauben Landskron, Tjasso Blokzijl, Héctor Molina, María‐Celeste Casanova, Yingying Cui, Moting Liu, Antonio M. Da Costa De Pina, Daniela Simian, María‐Julieta González, Rinse K. Weersma, Rodrigo Quera, Gerard Dijkstra, Klaas Nico Faber, Marcela A. Hermoso   +16 more
wiley   +1 more source

Structural basis for ligand promiscuity and high signaling activity of Kaposi's Sarcoma-associated Herpesvirus-encoded GPCR. [PDF]

Nat Commun
Park JB, Sahoo B, Sahoo AR, Kim D, Seo HD, Bowman J, Kwak MJ, Suh S, Buck M, Dai X, Jung JU.   +10 more
europepmc   +1 more source

Molecular mechanism for pancreatic β‐cell dysfunction and atherosclerosis and its therapeutic application: Importance of translational research bridging clinical practice and basic research

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction It is well‐known that when pancreatic β‐cells are chronically exposed to hyperglycemia under diabetic conditions, β‐cell function is gradually deteriorating. Although such phenomena were well‐known as β‐cell glucose toxicity in clinical practice, its molecular mechanism remained unknown.
Hideaki Kaneto, Tomohiko Kimura, Junpei Sanada, Yuichiro Iwamoto, Masashi Shimoda, Shuhei Nakanishi, Kohei Kaku   +6 more
wiley   +1 more source

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation. [PDF]

Front Immunol
Wang Z, Wang C, Zhao S, Gu C.
europepmc   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, EarlyView.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

Identification and Expression Analysis of G-Protein-Coupled Receptors Provide Insights into Functional and Mechanistic Responses to Herbivore-Induced Plant Volatiles of <i>Paracarophenax alternatus</i>. [PDF]

Int J Mol Sci
Lin R, Chu X, Zhang Y, Ke S, Zheng Y, Yu W, Zhang F, Wu S.   +7 more
europepmc   +1 more source