Results 301 to 310 of about 92,511 (354)
GPCR activation and GRK2 assembly by a biased intracellular agonist
Nature, 2023 Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gα_q and the arrestin-biased ligand SBI-553 provide insights into these interactions and a foundation for the design of arrestin ...
, Xin-heng He, Ming-Wei Wang
exaly +2 more sources
Trends in GPCR drug discovery: new agents, targets and indications
Nature Reviews Drug Discovery, 2017 Alexander S Hauser +2 more
exaly +2 more sources
Single-molecule FRET imaging of GPCR dimers in living cells
Nature Methods, 2021 Wesley B Asher +2 more
exaly +2 more sources
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Nature Chemical Biology, 2020 G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the transducerome) to exert their actions.
Jeffrey F Diberto +2 more
exaly +2 more sources
GPCR Dynamics: Structures in Motion
Chemical Reviews, 2017 Naomi R Latorraca, A J Venkatakrishnan
exaly +2 more sources
Combinatorial expression of GPCR isoforms affects signalling and drug responses
Nature, 2020 Maria Marti-Solano +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Recent Progress in Assays for GPCR Drug Discovery.
American Journal of Physiology - Cell Physiology, 2022G-protein coupled receptors (GPCRs), also known as 7 transmembrane receptors, are the largest family of cell surface receptors in eukaryotes. There are ~800 GPCRs in human, regulating diverse physiological processes.
Shimeng Guo +3 more
semanticscholar +1 more source
Life Sciences, 2003
The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
openaire +2 more sources
The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
openaire +2 more sources