Results 301 to 310 of about 113,722 (335)

AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist. [PDF]

J Cheminform
Brahma R, Moon S, Shin JM, Cho KH.
europepmc   +1 more source

N‐Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 5, July 2025.
ABSTRACT N‐lactoyl amino acids (Lac‐AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various biochemical processes. This narrative review aims to provide a comprehensive overview of the current understanding of Lac‐AA,
Khaled Naja, Laila Hedaya, Asma A. Elashi, Manfredi Rizzo, Mohamed A. Elrayess   +4 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling. [PDF]

Front Endocrinol (Lausanne)
Song W, Li Y, Xu H, Zhang Y, Liu L, Li Y, Wang X, Du Y, Chen Y, Lyu J, Jin L, Zhang C, Xiao Y.   +12 more
europepmc   +1 more source

Apo‐state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Yasushi Kondo, Caitlin Hatton, Robert Cheng, Matilde Trabuco, Hannah Glover, Quentin Bertrand, Fabienne Stierli, Hans‐Peter Seidel, Thomas Mason, Sivathmika Sarma, Friedjof Tellkamp, Michal Kepa, Florian Dworkowski, Pedram Mehrabi, Michael Hennig, Joerg Standfuss   +15 more
wiley   +1 more source

The effects of liraglutide on expressions of insulin secretion and beta cell survive associated GPCR genes in pancreatic beta cells. [PDF]

Turk J Med Sci
Türkol M, Bilgen T.
europepmc   +1 more source

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective. [PDF]

Innovation (Camb)
Bi Z, Li H, Liang Y, Sun D, Liu S, Chen W, Leng L, Song C, Zhang S, Cong Z, Chen S.   +10 more
europepmc   +1 more source

Exploring the evolutionary journey of the lumpy skin disease virus through the phylogenetic and phylo-geo network analysis. [PDF]

Front Cell Infect Microbiol
Bayyappa MRG, Pyatla MKG, Pabbineedi SM, Gunturu NT, Peela SM, Nagaraj S, Tadakod S, Gandham RK, Gulati BR.   +8 more
europepmc   +1 more source

Artificial Intelligence: A New Tool for Structure-Based G Protein-Coupled Receptor Drug Discovery. [PDF]

Biomolecules
Chung J, Hahn H, Flores-Espinoza E, Thomsen ARB.   +3 more
europepmc   +1 more source

Lineage-Specific Class-A GPCR Dynamics Reflect Diverse Chemosensory Adaptations in Lophotrochozoa. [PDF]

Mol Biol Evol
Nath R, Panda B, Rakesh S, Krishnan A.
europepmc   +1 more source