Results 61 to 70 of about 61,419 (246)
Catalysis in Chemical Modification of Proteins
ChemCatChem, Accepted Article.Advancement of catalytic transformations in traditional synthetic organic chemistry have made significant impacts on development of novel bioconjugation technologies. While a wide range of applications have become possible through catalytic protein bioconjugation approaches, there has been a lack of literature collectively reviewing advances of ...
Seiya Ishizawa +4 more
wiley +1 more source
Chemistry – A European Journal, Accepted Article.Short amyloidogenic oligopeptides (APRs) are proposed as early macromolecules capable of forming solvent‐separated nanosystems under prebiotic conditions. This study provides experimental evidence that APRs, such as the aggregation‐prone oligopeptide A (APR‐A), can undergo mutational transitions to form distinct variants, and convert to APR‐B, either ...
Fruzsina Bencs +7 more
wiley +1 more source
FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022 Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas +4 more
wiley +1 more source
Frontiers in Endocrinology, 2013 A G protein-coupled receptor (GPCR) functions not only as a monomer or homodimer but also as a heterodimer with another GPCR. GPCR heterodimerization results in the modulation of the molecular functions of the GPCR protomer, including ligand binding ...
Honoo eSatake +4 more
doaj +1 more source
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
ChemMedChem, EarlyView.This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino +7 more
wiley +1 more source
Agonist and antagonist TRUPATH assays for G protein-coupled receptors
STAR Protocols, 2022 Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto +3 more
doaj
ChemMedChem, Accepted Article.The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid +8 more
wiley +1 more source
Editorial: Insights in cellular endocrinology: 2022
Frontiers in Endocrinology, 2023 Ralf Jockers, Oreste Gualillo
doaj +1 more source
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Current Research in Pharmacology and Drug Discovery, 2022 GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form ...
Haifeng Eishingdrelo +4 more
doaj
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source