Results 61 to 70 of about 142,523 (351)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Differential Regulation of GPCRs—Are GRK Expression Levels the Key?

Frontiers in Cell and Developmental Biology, 2021
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Edda S. F. Matthees, Raphael S. Haider, Carsten Hoffmann, Julia Drube   +3 more
doaj   +1 more source

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa. [PDF]

, 2015
G protein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein ...
Ahrendt, Steven R, Barsoum, Andrew H, Borkovich, Katherine A, Cabrera, Ilva E, Cao, Jackie, Carrillo, Alexander J, Castillo, Ronald, Chen, Wan-Ching, Davidson, Liza M, Dinkchian, Alex, Guerrero, Nayeli, Kim, Stephanie, Kitada, Sho M, Krystofova, Svetlana, Lai, Taffani H, Li, Liande, Lim, Andrew, Mach, Ashley, Malekyan, Cristin, Michkov, Alexander V, Moua, Toua R, Pacentine, Itallia V, Servin, Jacqueline A, Torres, Carlos Rojas, Yamamoto, Alaina   +24 more
core  

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]

, 2017
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S., Blanco, Francisco J., Blanco-Canosa, Juan B., Cerione, Richard A., de la Cruz-Morcillo, Miguel Angel, DiGiacomo, Vincent, Garcia-Marcos, Mikel, Ibáñez de Opakua, Alain, Leyme, Anthony, Marivin, Arthur, Merino, Nekane, Nguyen, Lien T., Parag-Sharma, Kshitij, Ramachandran, Sekar, Villate, Maider   +14 more
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex

Nature Structural & Molecular Biology, 2019
Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (β-arr).
Anthony H. Nguyen, A. Thomsen, T. Cahill, Rick Huang, Li-Yin Huang, T. Marcink, O. Clarke, Søren Heissel, A. Masoudi, Danya Ben-Hail, Fadi Samaan, V. Dandey, Yong Zi Tan, C. Hong, Jacob P. Mahoney, Sarah Triest, John Little, Xin Chen, Roger Sunahara, J. Steyaert, H. Molina, Zhiheng Yu, Amédée des Georges, R. Lefkowitz   +23 more
semanticscholar   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source