Results 71 to 80 of about 61,419 (246)

GPCR signaling regulates severe stress‐induced organismic death in Caenorhabditis elegans

Aging Cell, Volume 22, Issue 1, January 2023., 2023
C. elegans rapidly dies upon the exposure to severe freezing‐thaw stress in a regulated fashion (stress‐induced phenoptosis). Signaling from G‐protein‐coupled receptor FSHR‐1 promotes stress‐induced gene expression and phenoptosis. Findings are of implications to the evolutionary kin selection theory and the disposable soma hypothesis of aging ...
Changnan Wang, Yong Long, Bingying Wang, Chao Zhang, Dengke K. Ma   +4 more
wiley   +1 more source

G protein-coupled receptors: the evolution of structural insight

AIMS Biophysics, 2017
G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins that have gained relevance as biological targets for pharmaceutical drug design.
Samantha B. Gacasan, Daniel L. Baker, Abby L. Parrill   +2 more
doaj   +1 more source

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source

Chipping away at GPCR function [PDF]

, 1999
Kevin Beaumont, Paul A. Negulescu
openalex   +1 more source

Association of ventricular–arterial coupling with biomarkers involved in heart failure pathophysiology – the STANISLAS cohort

European Journal of Heart Failure, EarlyView.
Association of ventricular–arterial coupling with heart failure (HF) biomarkers in the STANISLAS cohort. MMP, matrix metalloproteinase; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide. Aims Impaired left ventricular–arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF).
Hannes Holm, Martin Magnusson, Amra Jujić, Jérémy Lagrange, Erwan Bozec, Zohra Lamiral, Emmanuel Bresso, Olivier Huttin, Guillaume Baudry, Luca Monzo, Patrick Rossignol, Faiez Zannad, Nicolas Girerd   +12 more
wiley   +1 more source

NCD3G: a novel nine-cysteine domain in family 3 GPCRs [PDF]

, 2004
Xiang-hua Liu, Quanyuan He, David J. Studholme, Qi Wu, Songping Liang, Yu Long   +5 more
openalex   +2 more sources

A new variant of lumpy skin disease virus circulating in Vietnam based on sequencing analysis of GPCR gene

Open Veterinary Journal
Background: In 2021, Vietnam experienced an outbreak of Lumpy skin disease (LSD), which infected 207,687 cattle and buffaloes, as officially reported, and resulted in the culling of 29,182 animals.
Ha Thi Thanh Tran, Anh Duc Truong, Anh Tuan Tran, Nhu Thi Chu, Vinh The Nguyen, Hoang Vu Dang   +5 more
doaj   +1 more source

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Head &Neck, EarlyView.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells.
Kimberly Wei, Brianna L. Hill, Joel C. Thompson, Zoey A. Miller, Arielle Mueller, Robert J. Lee, Ryan M. Carey   +6 more
wiley   +1 more source

Neoceptor Concept Based on Molecular Complementarity in GPCRs: A Mutant Adenosine A₃ Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides [PDF]

, 2001
Kenneth A. Jacobson, Zhan‐Guo Gao, Aishe Chen, Dov Barak, Soon‐Ai Kim, Kyeong Lee, Andreas Link, Philippe Van Rompaey, Serge Van Calenbergh, Bruce T. Liang   +9 more
openalex   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source