Results 71 to 80 of about 113,722 (335)
Advanced Science, EarlyView.Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge +10 more
wiley +1 more source
Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. [PDF]
, 2019 Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream ...
Mohanty, Ipsita +2 more
core +1 more source
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]
, 2009 G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den +8 more
core +1 more source
A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice
Advanced Science, EarlyView.OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang +9 more
wiley +1 more source
Brain Sciences, 2019 The molecular pathways underlying the induction and maintenance of long-term synaptic plasticity have been extensively investigated revealing various mechanisms by which neurons control their synaptic strength.
Amjad H. Bazzari, H. Rheinallt Parri
doaj +1 more source
Frontiers in Immunology, 2020 Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are the consequence of the cellular environment, which is highly variable.
Gabriela Riemekasten +7 more
doaj +1 more source
G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 [PDF]
, 2017 It is widely appreciated that G protein-coupled receptors have been the most successfully exploited class of targets for the development of small molecule medicines. Despite this, to date, less than 15% of the non-olfactory G protein-coupled receptors in
Milligan, Graeme
core +1 more source
GPCR regulation of secretion [PDF]
Pharmacology & Therapeutics, 2018 Modulation of neurotransmitter exocytosis by activated Gi/o coupled G-protein coupled receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation and to influence circuitry. One of the known modulation mechanisms is the interaction between Gβγ and the soluble N-ethylmaleimide-sensitive factor attachment protein receptor ...
Yun Young Yim +2 more
openaire +3 more sources
Advanced Science, EarlyView.This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu +18 more
wiley +1 more source
Ontogeny of the specificity of gonadotropin receptors and gene expression in carp
Endocrine Connections, 2019 The pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are the principle endocrine drivers of reproductive processes in the gonads of jawed vertebrates.
Lian Hollander-Cohen +3 more
doaj +1 more source