Results 81 to 90 of about 142,523 (351)
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
Science Signaling, 2018 β-Arrestin proteins fine-tune different GPCR-stimulated pathways that converge on ERK1/2 activation. The balancing act of β-arrestins G protein–coupled receptors (GPCRs) are thought to activate the kinases ERK1/2 through G protein– and β-arrestin ...
L. Luttrell +18 more
semanticscholar +1 more source
Probiotic‐Based Materials as Living Therapeutics
Advanced Materials, EarlyView.Recent advances in Engineered Living Materials are highlighted, integrating synthetic biology and advanced materials, with a focus on probiotic‐based therapeutics. Probiotic Living Materials hold great potential for biosensing, infection treatment, osteogenesis, wound healing, vaginal and gastrointestinal disorders, and cancer therapy. breakthroughs in
Laura Sabio +2 more
wiley +1 more source
Open Veterinary JournalBackground: Lumpy skin disease (LSD) is caused by a virus belonging to the genus Capripoxvirus, exhibiting clinical symptoms ranging from mild signs to the development of nodules.
Tran Ngoc Bich +6 more
doaj +1 more source
Dampening of neurotransmitter action: molecular similarity within the melatonin structure
Endocrine Regulations, 2018 Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj +1 more source
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
Nature Chemical Biology, 2020 The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies.
Signe Mathiasen +11 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Biological and biologically‐inspired functional nanostructures with structural, thermal, optical, and sensing applications are reviewed. The role of nanoscale features in biological materials on performance is described, and their blueprints are used for bio‐inspired nanomaterials, synthesized using advanced techniques (i.e., photolithography, bio ...
Chao Hsuan (Joseph) Sung +15 more
wiley +1 more source
TBXA2R gene variants associated with bleeding
Platelets, 2018 Platelet activity is regulated by a number of surface expressed G protein-coupled receptors (GPCRs) including the α isoform of the thromboxane receptor (TPα receptor). With the advance of genomic technologies, there has been a substantial increase in the
Stuart James Mundell, Andrew Mumford
doaj +1 more source
Deep hierarchical embedding for simultaneous modeling of GPCR proteins in a unified metric space
Scientific Reports, 2021 GPCR proteins belong to diverse families of proteins that are defined at multiple hierarchical levels. Inspecting relationships between GPCR proteins on the hierarchical structure is important, since characteristics of the protein can be inferred from ...
Taeheon Lee +3 more
doaj +1 more source
The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]
, 2014 The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D. +3 more
core +1 more source
Advanced Science, EarlyView.TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino +16 more
wiley +1 more source