Results 111 to 120 of about 41,935 (256)
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Optical functionalization of human Class A orphan G-protein-coupled receptors
Nature Communications, 2018 G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ...
Maurizio Morri +7 more
doaj +1 more source
, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites.
Choi, Sun, Hyeon, Changbong, Lee, Yoonji
core +3 more sources
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Gi/o-Protein Coupled Receptors in the Aging Brain
Frontiers in Aging Neuroscience, 2019 Cells translate extracellular signals to regulate processes such as differentiation, metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors (GPCRs) belong to the largest family of transmembrane receptors, with over 800 ...
Patrícia G. de Oliveira +4 more
doaj +1 more source
Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle
Advanced Science, EarlyView.Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong +7 more
wiley +1 more source
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]
, 2011 Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun +3 more
core +2 more sources
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Advanced Science, EarlyView.Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan +11 more
wiley +1 more source
ReceptorsBoron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana +6 more
doaj +1 more source