Results 91 to 100 of about 67,843 (252)
β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels
Epilepsia, EarlyView.β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi +8 more
wiley +1 more source
Circular Dichroism Spectra of Five Purified GPCRs.
, 2013 A) Cell-free expressed mOR103-15 made with Brij-35 or no detergent, B) Cell-free expressed hTAAR5, C) Cell-free expressed hFPR3, and D) Cell-free and HEK293 expressed hVN1R1.
Deepali B. Ravel (194820) +11 more
core +1 more source
Food Bioengineering, EarlyView.Fermentation enhances nutritional & techno‐functional properties of plant protein. Three distinct stages of fermentation impact on different aspects of plant protein. Fermentation induces flavors modulation through new organic compounds formation. Plant protein fermentation improves their utility in food applications.
Disha +3 more
wiley +1 more source
Mechanisms of membrane trafficking for G-protein-coupled receptors (GPCRs)
, 2011 Copyright information:Taken from "Trafficking of central opioid receptors and descending pain inhibition"http://www.molecularpain.com/content/3/1/37Molecular Pain 2007;3():37-37.Published online 4 Dec 2007PMCID:PMC2219988. Upon agonist binding (), a GPCR,
Bihua Bie (85332) +1 more
core +1 more source
Food Biomacromolecules, EarlyView.Effects of digestive products of quinoa, oat, barley, and mungbean proteins on GLP‐1 secretion are investigated using STC‐1 cell and animal experiments, and novel GLP‐1 secretion‐stimulating peptides are successfully identified by column chromatography and LC–MS/MS.
Hongdong Song +8 more
wiley +1 more source
Food Safety and Health, EarlyView.In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso +3 more
wiley +1 more source
GPCRs Revisited: New Insights Lead to Novel Drugs
, 2011 GPCRs play a critical role in human physiology and are a prime target for drug discovery globally. Novel insights into the functions of GPCRs are providing unique approaches to modulate these proteins to generate unique drug candidates.
Richard M. Eglen, Terry Reisine
core +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Modeling the interplay between membrane lipids and GPCRs [PDF]
, 2014 La composición lipídica de las membranas celulares determina en última instancia sus propiedades biofísicas, afectando así las dinámicas y organización de proteinas transmembrana claves como los receptores acoplados a proteínas G (GPCRs).
Guixà González, Ramon +1 more
core
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source