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Privileged Structures in GPCRs
2007Certain kinds of ligand substructures recur frequently in pharmacologically successful synthetic compounds. For this reason they are called privileged structures. In seeking an explanation for this phenomenon, it is observed that the privileged structure represents a generic substructure that matches commonly recurring conserved structural motifs in ...
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Current Opinion in Structural Biology, 2019
Molecular switches in GPCRs enable passing the signal from the agonist binding site, usually located close to the extracellular surface, to the intracellular part of the receptor. The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to
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Molecular switches in GPCRs enable passing the signal from the agonist binding site, usually located close to the extracellular surface, to the intracellular part of the receptor. The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to
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Nature Methods, 2010
Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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Researchers solve a high-resolution structure of a seven-helix transmembrane protein using nuclear magnetic resonance (NMR) spectroscopy.
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Allosteric Modulation of GPCRs of Class A by Cholesterol
International Journal of Molecular Sciences, 2021Jan Jakubik, Esam E El-Fakahany
exaly
Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation
Molecular Cell, 2023Jagannath Maharana +2 more
exaly
Cholesterol in Class C GPCRs: Role, Relevance, and Localization
Membranes, 2023Ugochi H Isu +2 more
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