Results 181 to 190 of about 10,884 (213)

GPER Promoter Methylation Controls GPER Expression in Breast Cancer Patients

Cancer Investigation, 2017
Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we analyzed GPER promoter methylation in 260 primary breast cancer specimens by methylation-specific polymerized chain reaction.
Christine, Weissenborn, Tanja, Ignatov, Norbert, Nass, Thomas, Kalinski, Serban, Dan Costa, Ana Claudia, Zenclussen, Atanas, Ignatov   +6 more
openaire   +2 more sources

Recent Advances in the Rationale Design of GPER Ligands

Current Medicinal Chemistry, 2012
G-Protein Coupled Receptor (GPCR) superfamily, which comprises approximately 900 members, is the largest family of protein targets with proven therapeutic value. Although at least 500 GPCRs have been identified as therapeutically relevant, only thirteen GPCRs have been structurally characterized in apo-form or in complex with ligands.
Rosano C, Lappano R, Santolla MF, Ponassi M, Donadini A, MAGGIOLINI, Marcello   +5 more
openaire   +2 more sources

Interaction of nuclear ERs and GPER in vitellogenesis in zebrafish

The Journal of Steroid Biochemistry and Molecular Biology, 2019
Estrogens exert their biological functions through the estrogen receptors (ERs). In zebrafish, three nuclear estrogen receptors (nERs) named ERα, ERβ1 and ERβ2 and one membrane-bound G protein-coupled estrogen receptor (GPER) are identified. Vitellogenin (Vtg) is predominantly expressed in liver and strongly response to the stimulation of estrogen.
Yu, Chen, Haipei, Tang, Jianan, He, Xi, Wu, Le, Wang, Xiaochun, Liu, Haoran, Lin   +6 more
openaire   +2 more sources

Unraveling the Role of GPER in Breast Cancer

2011
The G protein-coupled estrogen receptor-1 (GPER, formerly called GPR30) has been recently involved in the multifaceted transduction pathways through which estrogens induce diverse biological responses as well as pathological processes, including cancer development and progression.
Lappano R., Maggiolini M.
openaire   +1 more source

Sex differences in vascular aging and impact of GPER deletion

American Journal of Physiology-Heart and Circulatory Physiology, 2022
Indices of vascular aging were different in male and female mice. Sex differences in pulse wave velocity, blood pressure, and large artery stiffness were abrogated in middle-aged mice, but the female advantage in resistance artery vasodilator function was maintained.
Benard O. Ogola, Caleb M. Abshire, Bruna Visniauskas, Jasmine X. Kiley, Alec C. Horton, Gabrielle L. Clark-Patterson, Isabella Kilanowski-Doroh, Zaidmara Diaz, Anne N. Bicego, Alexandra B. McNally, Margaret A. Zimmerman, Leanne Groban, Aaron J. Trask, Kristin S. Miller, Sarah H. Lindsey   +14 more
openaire   +2 more sources

GPER Mediates Non-Genomic Effects of Estrogen

2016
Estrogens are important modulators of a broad spectrum of physiological functions in humans. However, despite their beneficial actions, a number of lines of evidence correlate the sustained exposure to exogenous estrogen with increased risk of the onset of various cancers.
Pupo M, MAGGIOLINI, Marcello, MUSTI, Anna Maria   +2 more
openaire   +3 more sources

GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens

Cancer Research, 2014
Abstract Biological responses to estrogens in normal and malignant tissues are mainly mediated by the estrogen receptors ERα and ERβ, which function as ligand-activated transcription factors. In addition, the G protein–coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (
De Francesco EM, Pellegrino M, Santolla MF, Lappano R, Ricchio E, Abonante S, MAGGIOLINI, Marcello   +6 more
openaire   +3 more sources

Cross-talk between GPER and growth factor signaling

The Journal of Steroid Biochemistry and Molecular Biology, 2013
G protein-coupled receptors (GPCRs) and growth factor receptors mediate multiple physio-pathological responses to a diverse array of extracellular stimuli. In this regard, it has been largely demonstrated that GPCRs and growth factor receptors generate a multifaceted signaling network, which triggers relevant biological effects in normal and cancer ...
Lappano R, De Marco P, De Francesco EM, Chimento A, PEZZI, Vincenzo, MAGGIOLINI, Marcello   +5 more
openaire   +4 more sources

The GPER Agonist G‐1 Induces Mitotic Arrest and Apoptosis in Human Vascular Smooth Muscle Cells Independent of GPER

Journal of Cellular Physiology, 2014
The G protein‐coupled estrogen receptor (GPER) has been implicated in the regulation of smooth muscle cell (SMC) proliferation. The GPER selective agonist G‐1 has been a useful tool for exploring the biological roles of GPER in a variety of experimental settings, including SMC proliferation.
Yu, Gui, Zhan, Shi, ZengYong, Wang, Jing-Jing, Li, Can, Xu, RuiJuan, Tian, XinXing, Song, Michael P, Walsh, Dong, Li, Jie, Gao, Xi-Long, Zheng   +10 more
openaire   +2 more sources

GPER-1 and sex-hormone levels in patients with otosclerosis

American Journal of Otolaryngology, 2020
Otosclerosis is a widespread disease but the etiopathogenesis is still not fully understood. Hormonal factors especially estrogens are accused in recent years. The study aimed to evaluate the levels of G-protein associated membrane estrogen receptor-1 (GPER-1) and sex-hormones in patients with otosclerosis.The study included 60 people (30 otosclerosis ...
Duygu Erdem, Aykut Erdem Dinç, Berrak Guven, Sultan Şevik Eliçora   +3 more
openaire   +3 more sources