Results 141 to 150 of about 19,033 (167)

Calmodulin regulates GPER/GPR30‐mediated signaling

The FASEB Journal, 2016
The G protein‐coupled estrogen receptor 1 (GPER/GPR30) was recently identified as a novel receptor for estrogen, and has been demonstrated to be involved in numerous processes in various organ systems. However, its regulatory inputs are not entirely understood. Calmodulin (CaM) is the ubiquitous transducer of Ca
Vahe Matnishian, Jake Jasurda, Phuong Tran, Mark VerMeer, QUANG‐KIM TRAN   +4 more
openaire   +1 more source

GPR30 Signaling and Regulation in Breast Cancer

2011
Abstract : Estrogen plays a significant role in the progression of breast cancer, leading to increased growth of breast tumors. Until 2005, the classical estrogen receptor, ER , was believed to modulate the entirety of E2-dependent breast cancer growth.
openaire   +1 more source

GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice

Biology of Reproduction, 2009
The G protein-coupled receptor Gpr30 (Gper) was recently claimed to bind to estradiol and to activate cytoplasmic signal transduction pathways in response to estradiol. However, there are conflicting data regarding the role of Gpr30 as an estrogen receptor (ER): several laboratories were unable to demonstrate estradiol binding to GPR30 or estradiol ...
Christiane, Otto, Iris, Fuchs, Gunther, Kauselmann, Heidrun, Kern, Branko, Zevnik, Puk, Andreasen, Gilda, Schwarz, Helga, Altmann, Mario, Klewer, Michael, Schoor, Richardus, Vonk, Karl-Heinrich, Fritzemeier   +11 more
openaire   +2 more sources

Role of GPR30 in endometrial pathology after tamoxifen for breast cancer

American Journal of Obstetrics and Gynecology, 2010
This study was undertaken to evaluate the potential role of G-protein-coupled estrogen receptor in endometrial pathology associated with tamoxifen treatment of breast cancer patients.We investigated whether G-protein-coupled estrogen receptor plays a role in mediating proliferating effect of tamoxifen in endometrial carcinoma cells.
Tanja, Ignatov, Holm, Eggemann, Andrzej, Semczuk, Bobbie, Smith, Joachim, Bischoff, Albert, Roessner, Serban D, Costa, Thomas, Kalinski, Atanas, Ignatov   +8 more
openaire   +2 more sources

Biology of the estrogen receptor, GPR30, in triple negative breast cancer

The American Journal of Surgery, 2013
Triple-negative (TN) breast cancer lacks a known signaling pathway amenable to targeted therapy. The authors hypothesized that the G protein-coupled receptor GPR30 may be present in TN breast cancer and serve a role for tumor growth.A retrospective pathology study and chart review were conducted.
Jennifer, Steiman, Elizabeth A, Peralta, Somaja, Louis, Onsi, Kamel   +3 more
openaire   +2 more sources

Expression and function of GPR30 in human chondrocytes

Osteoarthritis and Cartilage, 2021
C. Sousa, M. Ribeiro, A.T. Rufino, F. Sousa, F. Judas, A.F. Mendes   +5 more
openaire   +1 more source

Exploring the metabolic role of GPR30 in mice

2020
Recent studies showed that GPR30, a seven-transmembrane G protein-coupled receptor, is a novel estrogen receptor (ER) that mediates some biological events elicited by estrogen in several types of cancer cells. However, its physiological or pathological role in vivo is unclear.
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Expression pattern of GPR30 in endometriosis

Geburtshilfe und Frauenheilkunde, 2011
EP Samartzis, N Samartzis, A Noske, A Fedier, R Caduff, D Fink, P Imesch   +6 more
openaire   +1 more source

Gpr30

AfCS-Nature Molecule Pages, 2006
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GPR30

2008
openaire   +1 more source