Results 131 to 140 of about 19,033 (167)
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GPR30: a novel indicator of poor survival for endometrial carcinoma
American Journal of Obstetrics and Gynecology, 2007This study was undertaken to evaluate the relationship between GPR30, classical steroidal receptor expression, and clinical outcome in patients with endometrial carcinoma.Immunohistochemistry was used to investigate the expression of GPR30, estrogen, progesterone, epidermal growth factor receptors and Ki-67 in 47 consecutive consenting patients with ...
Eric R Prossnitz +2 more
exaly +3 more sources
Reprint of ”GPR30 mediates estrogen rapid signaling and neuroprotection”
Molecular and Cellular Endocrinology, 2014G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective role in cerebral ischemia.
Mohammad Mushahid Khan +2 more
exaly +3 more sources
GPR30/GPER1: searching for a role in estrogen physiology
Trends in Endocrinology & Metabolism, 2009Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional ...
Björn, Olde, L M Fredrik, Leeb-Lundberg
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Animal Reproduction Science, 2013
G-protein - coupled receptor 30 (GPR30) is an estradiol receptor located on the plasma membrane, and it initiates several rapid, non-genomic signaling events. GPR30 has recently been identified in rat anterior pituitary (AP); however, little is known about the role of GPR30 in controlling luteinizing hormone (LH) secretion from gonadotropes in animals.
Faidiban O, Rudolf, Hiroya, Kadokawa
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G-protein - coupled receptor 30 (GPR30) is an estradiol receptor located on the plasma membrane, and it initiates several rapid, non-genomic signaling events. GPR30 has recently been identified in rat anterior pituitary (AP); however, little is known about the role of GPR30 in controlling luteinizing hormone (LH) secretion from gonadotropes in animals.
Faidiban O, Rudolf, Hiroya, Kadokawa
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A critical review of fundamental controversies in the field of GPR30 research
Steroids, 2010The female sex hormone estradiol plays an important role in reproduction, mammary gland development, bone turnover, metabolism, and cardiovascular function. The effects of estradiol are mediated by two classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).
Patricia Ruiz Noppinger +2 more
exaly +3 more sources
Activation of the GPR30 Receptor Promotes Lordosis in Female Mice
Neuroendocrinology, 2014<b><i>Background/Aims:</i></b> Estrogens are important effectors of reproduction and are critical for upregulating female reproductive behavior or lordosis in females. In addition to the importance of transcriptional regulation of genes by 17β-estradiol-bound estrogen receptors (ER), extranuclear signal transduction cascades ...
Divya, Anchan +4 more
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GPR30: a novel therapeutic target in estrogen-related disease
Trends in Pharmacological Sciences, 2008Estrogen is a crucial hormone in human physiology that regulates a multitude of biological processes. It is also an important target in many diseases such as cancer and skeletal, neurological and immunological conditions. The actions of estrogen have traditionally been ascribed to one of two closely related classical nuclear hormone receptors, ERalpha ...
Eric R, Prossnitz +3 more
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Journal of Cellular Physiology, 2020
AbstractMyocardial ischemia–reperfusion (I/R) injury, a major contributor to morbidity and mortality, represents a combination of intrinsic cellular response to ischemia and the extrinsic acute inflammatory response. In the present study, microarray analysis of GSE67308 and GSE50885 identified differentially expressed GPR30 and upstream regulatory miR ...
Lijie Zhu +5 more
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AbstractMyocardial ischemia–reperfusion (I/R) injury, a major contributor to morbidity and mortality, represents a combination of intrinsic cellular response to ischemia and the extrinsic acute inflammatory response. In the present study, microarray analysis of GSE67308 and GSE50885 identified differentially expressed GPR30 and upstream regulatory miR ...
Lijie Zhu +5 more
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Synthetic Estrogen Derivatives Demonstrate the Functionality of Intracellular GPR30
ACS Chemical Biology, 2007Estrogen mediates its effects through multiple cellular receptors. In addition to the classical nuclear estrogen receptors (ERalpha and ERbeta), estrogen also signals through the seven-transmembrane G-protein-coupled receptor (GPCR) GPR30. Although estrogen is a cell-permeable ligand, it is often assumed that all GPCRs function solely as cell surface ...
Chetana M, Revankar +8 more
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Virtual and biomolecular screening converge on a selective agonist for GPR30
Nature Chemical Biology, 2006Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the soluble, nuclear ligand-activated family of transcription factors.
Cristian G, Bologa +11 more
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