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GPR54 and kisspeptins in vertebrates, from fish to mammals

, 2021
Since the discovery of KISS/GPR54 pair in mammals, distinct kisspeptin forms have been reported in non-mammalian vertebrates, including reptilian, amphibian and fish. There is also evidence that multiple forms of kisspeptin receptors, up to four GPR54 paralogs, appear to exist in vertebrates.
Felip, Alicia, Espigares, F., Escobar, Sebastián, Alvarado, M. V., Zanuy, Silvia, Carrillo, Manuel, Gómez, Ana   +6 more
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GPR54 and rGnRH I gene expression during the onset of puberty in Nile tilapia [PDF]

General and Comparative Endocrinology, 2008
The Kiss1/GPR54 system has recently been shown to play a key role in the onset of puberty in mammals. Growing evidence suggests that this system is also conserved across vertebrates although very few studies so far have been performed in lower ...
Cristian Martinez, Hervé Migaud, Matteo Minghetti   +2 more
exaly   +2 more sources

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The GPR54 Gene as a Regulator of Puberty

Obstetrical & Gynecological Survey, 2003
Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus. We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty.We used complementary genetic ...
Stephanie B, Seminara, Sophie, Messager, Emmanouella E, Chatzidaki, Rosemary R, Thresher, James S, Acierno, Jenna K, Shagoury, Yousef, Bo-Abbas, Wendy, Kuohung, Kristine M, Schwinof, Alan G, Hendrick, Dirk, Zahn, John, Dixon, Ursula B, Kaiser, Susan A, Slaugenhaupt, James F, Gusella, Stephen, O'Rahilly, Mark B L, Carlton, William F, Crowley, Samuel A J R, Aparicio, William H, Colledge   +19 more
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Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

Molecular and Cellular Endocrinology, 2006
Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Mutations or targeted deletions of GPR54 produce isolated hypogonadotropic hypogonadism in humans and mice, indicating that signaling through this receptor is a prerequisite for ...
M L, Gottsch, D K, Clifton, R A, Steiner
openaire   +2 more sources

Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates

Proceedings of the National Academy of Sciences of the United States of America, 2005
To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the expression of GPR54 ...
Stephanie Seminara, Claudio Mastronardi, Tony Plant   +2 more
exaly   +2 more sources

GPR54 and puberty

Trends in Endocrinology & Metabolism, 2004
At puberty, pulsatile secretion of hormones initiates sexual maturation of the gonads. The G-protein-coupled receptor GPR54 is crucially involved in the initiation of puberty, along with its ligand metastin. Mice lacking GPR54 fail to undergo puberty and have immature reproductive organs and low levels of sex steroids and gonadotrophic hormones, but ...
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The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction

Annual Review of Physiology, 2008
Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal forebrain and drive reproductive function in mammals. Understanding the circuitry that regulates GnRH neurons is fundamental to comprehending the neuroendocrine control of puberty and reproduction in the adult.
Simina M, Popa, Donald K, Clifton, Robert A, Steiner   +2 more
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GPR54 Polymorphisms in Chinese Girls with Central Precocious Puberty

Neuroendocrinology, 2007
<i>Aims:</i> The <i>GPR54</i> gene has been proved to be important in the process of puberty onset, yet no association study has been performed to evaluate the effect of polymorphisms in the gene on central precocious puberty (CPP).
X, Luan, H, Yu, X, Wei, Y, Zhou, W, Wang, P, Li, X, Gan, D, Wei, J, Xiao   +8 more
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Local expressions and function of Kiss1/GPR54 in goats' testes

Gene, 2020
Kisspeptin, encoded by the Kiss1 gene, and its receptor GPR54 have a central regulatory role in the male reproduction. However, their functions in peripheral tissues, such as testes, remain unclear. This study investigated the local expressions and function of Kiss1/GPR54 in goats' testes.
Yanguo Han, Xiaoli Peng, Weijiang Si, Guiqiong Liu, Yuqing Han, Xunping Jiang, Risu Na, Liguo Yang, Jiayuan Wu, Guangxin E, Yan Zeng, Yongju Zhao, Yongfu Huang   +12 more
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Co-localization of GPR54 with three GnRHs and quantification of GPR54 protein in Atlantic croaker brain

2008
Recent studies have demonstrated that the G protein-coupled receptor 54 (GPR54) and its natural ligand kisspeptin (KiSS) play important roles in the control of puberty and reproductive maturation in mammals. In addition, GPR54 mRNA has been localized on the neurons expressing three GnRH mRNAs in tilapia (Parhar et al., 2004).
Khan, Izhar A., Mohamed, Shaik, Kline, Richard J., Galima, Maelanie M.   +3 more
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