Results 161 to 170 of about 4,400 (198)
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Roles of the Kisspeptin/GPR54 System in Pathomechanisms of Atherosclerosis
Nutrition, Metabolism and Cardiovascular Diseases, 2020Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention with respect to atherosclerosis, since both KP-10 and GPR54 are expressed at high levels in atheromatous plaques and restenotic lesions after wire-injury.
Kengo Sato, Takuya Watanabe
exaly +3 more sources
The GPR54 Gene as a Regulator of Puberty
New England Journal of Medicine, 2003Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus. We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty.We used complementary genetic ...
Stephanie B Seminara +2 more
exaly +3 more sources
Reviews in Endocrine and Metabolic Disorders, 2007
Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by absence of sexual maturation in the setting of low sex steroids and low/normal gonadotropins. Despite its rarity, considerable genetic heterogeneity and phenotypic variability exists in this disorder.
Felecia, Cerrato, Stephanie B, Seminara
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Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by absence of sexual maturation in the setting of low sex steroids and low/normal gonadotropins. Despite its rarity, considerable genetic heterogeneity and phenotypic variability exists in this disorder.
Felecia, Cerrato, Stephanie B, Seminara
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Local expressions and function of Kiss1/GPR54 in goats' testes
Gene, 2020Kisspeptin, encoded by the Kiss1 gene, and its receptor GPR54 have a central regulatory role in the male reproduction. However, their functions in peripheral tissues, such as testes, remain unclear. This study investigated the local expressions and function of Kiss1/GPR54 in goats' testes.
Yanguo Han +12 more
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Trends in Endocrinology & Metabolism, 2004
At puberty, pulsatile secretion of hormones initiates sexual maturation of the gonads. The G-protein-coupled receptor GPR54 is crucially involved in the initiation of puberty, along with its ligand metastin. Mice lacking GPR54 fail to undergo puberty and have immature reproductive organs and low levels of sex steroids and gonadotrophic hormones, but ...
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At puberty, pulsatile secretion of hormones initiates sexual maturation of the gonads. The G-protein-coupled receptor GPR54 is crucially involved in the initiation of puberty, along with its ligand metastin. Mice lacking GPR54 fail to undergo puberty and have immature reproductive organs and low levels of sex steroids and gonadotrophic hormones, but ...
openaire +2 more sources
Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis
Molecular and Cellular Endocrinology, 2006Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Mutations or targeted deletions of GPR54 produce isolated hypogonadotropic hypogonadism in humans and mice, indicating that signaling through this receptor is a prerequisite for ...
M L, Gottsch, D K, Clifton, R A, Steiner
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GPR54 And KiSS-1: Role in the Regulation of Puberty and Reproduction
Reviews in Endocrine and Metabolic Disorders, 2006The finding of inactivating mutations in GPR54 in IHH patients and the lack of reproductive maturation of the GPR54 null mouse have uncovered a previously unrecognized role for GPR54 and KiSS-1 in the physiologic regulation of puberty and reproduction.
Ursula Kaiser, Wendy Kuohung
exaly +3 more sources
GPR54 Polymorphisms in Chinese Girls With Central Precocious Puberty
Neuroendocrinology, 2007<i>Aims:</i> The <i>GPR54</i> gene has been proved to be important in the process of puberty onset, yet no association study has been performed to evaluate the effect of polymorphisms in the gene on central precocious puberty (CPP).
X Gan
exaly +3 more sources
Menstrual cyclic change of metastin/GPR54 in endometrium
Medical Molecular Morphology, 2014Metastin/kisspeptin is encoded by KISS1 and functions as an endogenous ligand of GPR54. Interaction of metastin with GPR54 suppresses metastasis and also regulates release of gonadotropin-releasing hormone, which promotes secretion of estradiol (E2) and progesterone (P4).
Tsukasa, Baba +12 more
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2008
Recent studies have demonstrated that the G protein-coupled receptor 54 (GPR54) and its natural ligand kisspeptin (KiSS) play important roles in the control of puberty and reproductive maturation in mammals. In addition, GPR54 mRNA has been localized on the neurons expressing three GnRH mRNAs in tilapia (Parhar et al., 2004).
Khan, Izhar A. +3 more
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Recent studies have demonstrated that the G protein-coupled receptor 54 (GPR54) and its natural ligand kisspeptin (KiSS) play important roles in the control of puberty and reproductive maturation in mammals. In addition, GPR54 mRNA has been localized on the neurons expressing three GnRH mRNAs in tilapia (Parhar et al., 2004).
Khan, Izhar A. +3 more
openaire +1 more source