Results 171 to 180 of about 4,400 (198)
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The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction
Annual Review of Physiology, 2008Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal forebrain and drive reproductive function in mammals. Understanding the circuitry that regulates GnRH neurons is fundamental to comprehending the neuroendocrine control of puberty and reproduction in the adult.
Simina M, Popa +2 more
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2008
The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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[GnRH resistance and the GPR54 gene].
Annales d'urologie, 2005Current data make it possible to relate idiopathic hypogonadotrophic hypogonadism to mutations affecting the GnRH I-1 receptor and also to new "loss-of-function" mutations concerning another receptor, GPR54. It now seems that mutations of the pituitary GnRH receptor are not the only explanation of most cases of sporadic isolated hypogonadotrophic ...
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GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency
Best Practice & Research Clinical Endocrinology & Metabolism, 2006Isolated hypogonadotropic hypogonadism (IHH) is defined by a complete or partial impaired secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In the regulation of the gonadotropic axis, the gonadotropin-releasing hormone (GnRH) and its receptor have evolved as a central element in fetal life, at puberty, and for reproduction ...
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Assessment of Constitutive Activity and Internalization of GPR54 (KISS1-R)
2010The kisspeptin/GPR54 signaling system positively regulates GnRH secretion, thereby acting as an important regulator of the hypothalamic-pituitary-gonadal axis. It also negatively regulates tumor metastases and placental trophoblast invasion. GPR54 is a G(q/11)-coupled GPCR and activation by kisspeptin stimulates PIP(2) hydrolysis and inositol phosphate
Macarena, Pampillo, Andy V, Babwah
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KiSS-1 and GPR54 as New Players in Gonadotropin Regulation and Puberty
Endocrine, 2005The recent identification of loss-of-function mutations in the gene encoding GPR54, the receptor for the KiSS-1-derived peptides, kisspeptins, has highlighted a previously unrecognized pathway in the physiologic regulation of puberty and reproduction. Patients with loss-of-function mutations in GPR54 have idiopathic hypogonadotropic hypogonadism, and ...
Ursula B, Kaiser, Wendy, Kuohung
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Role of Kisspeptin/GPR54 System in Human Reproductive Axis
2010The kisspeptin-GPR54 signaling complex is a key gatekeeper of human sexual maturation. Kisspeptins, encoded by the KISS1 gene, constitute a powerful stimulus for gonadotropin-releasing hormone-induced gonadotropin secretion. In addition, the KISS1 gene is a target for regulation by gonadal steroids in both sexes. The increase in hypothalamic kisspeptin
Leticia F G, Silveira +3 more
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Expression of a GPR54-like but no agonistic effect of mammalian kisspeptins in trout
2007Kisspeptins and their G protein-coupled receptor, play a fundamental role in the control of reproductive function in mammals. Here we show that the anterior brain and testis of the trout express a GPR54-like transcript. Trout at 3 stages of maturation were submitted to in vivo treatment with large amounts or repeated injections of mouse or human C ...
Goupil, Anne-Sophie +5 more
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Transgenic mouse models to study Gpr54/kisspeptin physiology
Peptides, 2009Four transgenic mouse lines have been generated with mutations in the Gpr54 gene and two lines with mutations in the Kiss1 gene. In general, the phenotypes of all these mutant mice are very similar and provide evidence that these molecules constitute an authentic receptor/ligand pair with no obvious redundancy or overlap with other signaling pathways ...
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Human diseases associated with GPR54 mutations.
Progress in molecular biology and translational science, 2011G protein-coupled receptor 54 (GPR54) was first described as an orphan receptor in the rat brain one decade ago. At that time, all we knew about this receptor was that it had a high homology with other G protein-coupled receptors, like galanin receptors. Later, its endogenous ligand, kisspeptin, was identified and the kisspeptin-GPR54 system became one
Milena Gurgel, Teles +3 more
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