Results 171 to 180 of about 4,181 (199)

Menstrual cyclic change of metastin/GPR54 in endometrium

Medical Molecular Morphology, 2014
Metastin/kisspeptin is encoded by KISS1 and functions as an endogenous ligand of GPR54. Interaction of metastin with GPR54 suppresses metastasis and also regulates release of gonadotropin-releasing hormone, which promotes secretion of estradiol (E2) and progesterone (P4).
Tsukasa, Baba, Hyun Sook, Kang, Yuko, Hosoe, Budiman, Kharma, Kaoru, Abiko, Noriomi, Matsumura, Junzo, Hamanishi, Ken, Yamaguchi, Yumiko, Yoshioka, Masafumi, Koshiyama, Masaki, Mandai, Susan K, Murphy, Ikuo, Konishi   +12 more
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GPR54 and Kisspeptins

2008
The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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[GnRH resistance and the GPR54 gene].

Annales d'urologie, 2005
Current data make it possible to relate idiopathic hypogonadotrophic hypogonadism to mutations affecting the GnRH I-1 receptor and also to new "loss-of-function" mutations concerning another receptor, GPR54. It now seems that mutations of the pituitary GnRH receptor are not the only explanation of most cases of sporadic isolated hypogonadotrophic ...
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Assessment of Constitutive Activity and Internalization of GPR54 (KISS1-R)

2010
The kisspeptin/GPR54 signaling system positively regulates GnRH secretion, thereby acting as an important regulator of the hypothalamic-pituitary-gonadal axis. It also negatively regulates tumor metastases and placental trophoblast invasion. GPR54 is a G(q/11)-coupled GPCR and activation by kisspeptin stimulates PIP(2) hydrolysis and inositol phosphate
Macarena, Pampillo, Andy V, Babwah
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Physical association of GPR54 C-terminal with protein phosphatase 2A

Biochemical and Biophysical Research Communications, 2008
KiSS1 was discovered as a metastasis suppressor gene and subsequently found to encode kisspeptins (KP), ligands for a G protein coupled receptor (GPCR), GPR54. This ligand-receptor pair was later shown to play a critical role in the neuro-endocrine regulation of puberty.
Barry J, Evans, Zixuan, Wang, La'Tonya, Mobley, Davood, Khosravi, Nobutaka, Fujii, Jean-Marc, Navenot, Stephen C, Peiper   +6 more
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GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency

Best Practice & Research Clinical Endocrinology & Metabolism, 2006
Isolated hypogonadotropic hypogonadism (IHH) is defined by a complete or partial impaired secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In the regulation of the gonadotropic axis, the gonadotropin-releasing hormone (GnRH) and its receptor have evolved as a central element in fetal life, at puberty, and for reproduction ...
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GPR54 and KiSS-1: Role in the regulation of puberty and reproduction

Reviews in Endocrine and Metabolic Disorders, 2006
The finding of inactivating mutations in GPR54 in IHH patients and the lack of reproductive maturation of the GPR54 null mouse have uncovered a previously unrecognized role for GPR54 and KiSS-1 in the physiologic regulation of puberty and reproduction.
Wendy, Kuohung, Ursula B, Kaiser
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Role of Kisspeptin/GPR54 System in Human Reproductive Axis

2010
The kisspeptin-GPR54 signaling complex is a key gatekeeper of human sexual maturation. Kisspeptins, encoded by the KISS1 gene, constitute a powerful stimulus for gonadotropin-releasing hormone-induced gonadotropin secretion. In addition, the KISS1 gene is a target for regulation by gonadal steroids in both sexes. The increase in hypothalamic kisspeptin
Leticia F G, Silveira, Milena G, Teles, Ericka B, Trarbach, Ana Claudia, Latronico   +3 more
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Human diseases associated with GPR54 mutations.

Progress in molecular biology and translational science, 2011
G protein-coupled receptor 54 (GPR54) was first described as an orphan receptor in the rat brain one decade ago. At that time, all we knew about this receptor was that it had a high homology with other G protein-coupled receptors, like galanin receptors. Later, its endogenous ligand, kisspeptin, was identified and the kisspeptin-GPR54 system became one
Milena Gurgel, Teles, Leticia Ferreira Gontijo, Silveira, Suzy, Bianco, Ana Claudia, Latronico   +3 more
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Transgenic mouse models to study Gpr54/kisspeptin physiology

Peptides, 2009
Four transgenic mouse lines have been generated with mutations in the Gpr54 gene and two lines with mutations in the Kiss1 gene. In general, the phenotypes of all these mutant mice are very similar and provide evidence that these molecules constitute an authentic receptor/ligand pair with no obvious redundancy or overlap with other signaling pathways ...
openaire   +2 more sources