Results 101 to 110 of about 8,521 (239)
Rapid ubiquitination of Syk following GPVI activation in platelets [PDF]
Blood, 2005 AbstractSpleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin.
Satya P. Kunapuli +5 more
openaire +3 more sources
Cancer Medicine, Volume 14, Issue 18, September 2025.Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh +4 more
wiley +1 more source
Model systems for platelet receptor shedding
Platelets, 2017 Platelet adhesion and aggregation at sites of vascular injury are crucial for hemostasis; however, under pathological conditions, they can cause myocardial infarction and stroke.
Markus Bender +2 more
doaj +1 more source
Pharmacological actions of nobiletin in the modulation of platelet function [PDF]
, 2015 Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents.
Ali, Marfoua +9 more
core +1 more source
PLoS ONE, 2011 Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in
Huzoor Akbar +7 more
openaire +5 more sources
Basic mechanisms of platelet receptor shedding
Platelets, 2017 Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease.
Robert K. Andrews, Elizabeth E. Gardiner
doaj +1 more source
, 2023 Platelets are blood cells that prevent the loss of extensive blood volumes, but also contribute to arterial thrombosis. After a vessel is injured, platelets become activated by the exposed collagen and aggregate together, forming a thrombus. Whilst this is a crucial process in hemostasis, platelets also become activated due to rupture of an ...
openaire +2 more sources
Activation of GPVI by collagen is regulated by α2β1 and secondary mediators [PDF]
Journal of Thrombosis and Haemostasis, 2003 We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin alpha(2)beta(1) in the activation of washed platelets by collagen in the presence of the alpha(IIb)beta(3) antagonist lotrafiban. The stimulation of protein tyrosine phosphorylation by a collagen suspension is markedly delayed in the presence of the above ...
Atkinson, B.T. +2 more
openaire +3 more sources
Liver International, Volume 45, Issue 9, September 2025.ABSTRACT Background Etiopathogenesis of porto‐sinusoidal vascular disorder (PSVD) is poorly known. The present study aimed to investigate alterations in gut barrier, bacterial translocation, and pro‐aggregating/pro‐coagulant state and their relationship with liver injury in patients with PSVD without portal hypertension (PH−) in comparison with PSVD ...
Diletta Overi +18 more
wiley +1 more source
Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. [PDF]
PLoS ONE, 2015 Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms.
Yongwei Zheng +7 more
doaj +1 more source