Results 101 to 110 of about 6,202 (185)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

Redox Biology, 2014
Background: Activation of the platelet-specific collagen receptor, glycoprotein (GP) VI, induces intracellular reactive oxygen species (ROS) production; however the relevance of ROS to GPVI-mediated platelet responses remains unclear.
T.G. Walsh, M.C. Berndt, N. Carrim, J. Cowman, D. Kenny, P. Metharom   +5 more
doaj   +1 more source

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Research and Practice in Thrombosis and Haemostasis
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Minka Zivkovic, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Jeroen Eikenboom, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Roger Schutgens, Rolf Urbanus, Carin Uyl, Jan Voorberg, Huan Zhang, Minka Zivkovic   +74 more
doaj   +1 more source

Defective collagen-induced platelet activation in two patients with malignant haemopathies is related to a defect in the GPVI-coupled signalling pathway [PDF]

, 2004
Marie Geneviève Huisse, Bernadette Boval, Patricia Hainaud, Annie Robert, Françoise Fauvel-Lafève, Martine Jandrot‐Perrus, Sylvia Bellucci   +6 more
openalex   +1 more source

Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism.

Thrombosis Research, 2023
A. Iding, B. Kremers, M. Nagy, A. Pallares Robles, H. ten Cate, H. Spronk, A. T. ten Cate‐Hoek   +6 more
semanticscholar   +1 more source

Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand.

Journal of Thrombosis and Haemostasis, 2023
Eleyna M. Martin, Joanne C. Clark, Samantha J Montague, Luis A Moran, Ying Di, Lily J Bull, Luke Whittle, Florije Raka, R. Buka, Idrees Zafar, C. Kardeby, Alexandre Slater, Steve P. Watson   +12 more
semanticscholar   +1 more source

Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention

Advances in Interventional Cardiology, 2017
Introduction: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-
Magdalena Sionova, Peter Blasko, Stepan Jirous, David Vindis, Richard Rokyta, Zuzana Motovska   +5 more
doaj   +1 more source

GPVI and α2β1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow [PDF]

, 2005
Kendra L. Sarratt, Hong Chen, Mary M. Zutter, Samuel A. Santoro, Daniel A. Hammer, Mark L. Kahn   +5 more
openalex   +1 more source

Platelets from Ehlers-Danlos Syndrome Patients Exhibit Reduced GPVI Levels and Impaired Integrin αIIbβ3 inside-out Signaling [PDF]

, 2023
Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Ivan Budnik, Aditi Jain, Rakeshkumar B. Patel, Steven R. Lentz, Anil K. Chauhan   +7 more
openalex   +1 more source

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.

PLoS Computational Biology, 2015
We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury.
Joanne L Dunster, Francoise Mazet, Michael J Fry, Jonathan M Gibbins, Marcus J Tindall   +4 more
doaj   +1 more source

The GPIbα intracellular tail - role in transducing VWF- and Collagen/GPVI-mediated signaling [PDF]

, 2020
Adela Constantinescu‐Bercu, Yuxiao Alice Wang, Kevin Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T. B. Crawley, Isabelle I. Salles‐Crawley   +6 more
openalex   +1 more source