Results 101 to 110 of about 8,801 (259)
British Journal of Pharmacology, Volume 182, Issue 9, Page 1957-1974, May 2025.Abstract Background and Purpose Shear‐induced platelet activation and aggregation (SIPA) play crucial roles in arterial thrombosis. Piezo1 is a mechanosensitive calcium channel that promotes platelet hyperactivation under pathological high‐shear conditions.
Yilin Wang +8 more
wiley +1 more source
Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators [PDF]
, 2015 Nucleotide-based drug candidates such as antisense oligonucleotides, aptamers, immunoreceptor-activating nucleotides, or (anti)microRNAs hold great therapeutic promise for many human diseases.
Advani +44 more
core +3 more sources
Proteolytic processing of platelet receptors [PDF]
, 2018 Platelets have a major role in hemostasis and an emerging role in biological processes including inflammation and immunity. Many of these processes require platelet adhesion and localization at sites of tissue damage or infection and regulated platelet ...
Gardiner, Elizabeth E
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
G6f-like is an ITAM-containing collagen receptor in thrombocytes. [PDF]
PLoS ONE, 2012 Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM).
Craig E Hughes +6 more
doaj +1 more source
Charakteristik der Thrombozyten-Oberflächenexpression von Glycoprotein VI bei Diabetes mellitus Typ 2 [PDF]
, 2006 The present analysis investigated the role of GPVI for platelet activation and platelet-mediated endothelial activation in patients with type 2 diabetes.
Li, Zhongyan
core
Health Science Reports, Volume 8, Issue 4, April 2025.ABSTRACT Background Atherosclerosis is the leading cause of cardiovascular disease (CVD). Historically, the management of atherosclerosis was focused on decreasing lipid profile levels; however, recent evidence demonstrated that platelets and leukocytes play an important role in forming and exacerbating atherosclerosis.
Ali Mortezaei +7 more
wiley +1 more source
Model systems for platelet receptor shedding
Platelets, 2017 Platelet adhesion and aggregation at sites of vascular injury are crucial for hemostasis; however, under pathological conditions, they can cause myocardial infarction and stroke.
Markus Bender +2 more
doaj +1 more source
Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke. [PDF]
, 2016 BACKGROUND: Platelets are essential to physiological hemostasis or pathological thrombus formation. Current antiplatelet agents inhibit platelet aggregation but leave patients at risk of systemic side-effects such as hemorrhage.
Induruwa, Isuru +2 more
core +2 more sources
Journal of Cellular and Molecular Medicine, 2021 Naphthalimide derivatives have multiple biological activities, including antitumour and anti‐inflammatory activities. We previously synthesized several naphthalimide derivatives; of them, compound 5 was found to exert the strongest inhibitory effect on ...
T. Shih +9 more
semanticscholar +1 more source